{"id":1315,"date":"2024-03-02T08:40:44","date_gmt":"2024-03-02T08:40:44","guid":{"rendered":"http:\/\/marseille-quince.com\/?page_id=1315"},"modified":"2024-05-25T12:04:02","modified_gmt":"2024-05-25T12:04:02","slug":"latest-research","status":"publish","type":"page","link":"https:\/\/marseille-quince.com\/zh\/latest-research\/","title":{"rendered":"\u6700\u65b0\u7814\u7a76"},"content":{"rendered":"<h1 class=\"wp-block-heading\">\u8afe\u8c9d\u723e\u91ab\u5b78\u734e-\u764c\u75c7\u514d\u75ab\u7642\u6cd5<\/h1>\n\n\n\n<figure class=\"wp-block-image\"><img fetchpriority=\"high\" decoding=\"async\" width=\"696\" height=\"282\" src=\"http:\/\/marseille-quince.com\/wp-content\/uploads\/2024\/05\/ch-research.png\" alt=\"\" class=\"wp-image-1412\" srcset=\"https:\/\/marseille-quince.com\/wp-content\/uploads\/2024\/05\/ch-research.png 902w, https:\/\/marseille-quince.com\/wp-content\/uploads\/2024\/05\/ch-research-350x123.png 350w, https:\/\/marseille-quince.com\/wp-content\/uploads\/2024\/05\/ch-research-300x105.png 300w, https:\/\/marseille-quince.com\/wp-content\/uploads\/2024\/05\/ch-research-768x270.png 768w, https:\/\/marseille-quince.com\/wp-content\/uploads\/2024\/05\/ch-research-18x6.png 18w\" sizes=\"(max-width: 696px) 100vw, 696px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"articleTitle\">\u8fa8\u8b58\u514d\u75ab\u7cfb\u7d71\u8a0a\u865f\u3000\u6291\u5236\u53ca\u91cd\u9ede\u653b\u64ca\u816b\u7624<\/h2>\n\n\n\n<p>2018\u5e74\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u6216\u91ab\u5b78\u734e\uff0c\u7531\u7f8e\u570b\u5fb7\u5dde\u5927\u5b78\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08The University of Texas M. D. Anderson Cancer Center, UT MDA\uff09\u7684\u827e\u5229\u68ee\uff08James P. Allison\uff09\u8207\u65e5\u672c\u4eac\u90fd\u5927\u5b78\uff08Kyoto University\uff09\u7684\u672c\u5eb6\u4f51\uff08Tasuku Honjo\uff09\u540c\u4eab \u6b8a\u69ae\uff0c\u5f97\u734e\u7684\u539f\u56e0\u70ba\u767c\u660e\u300c\u900f\u904e\u6291\u5236\u8ca0\u5411\u8abf\u63a7\u514d\u75ab\u529f\u80fd\u904b\u4f5c\u7684\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u300d\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"articleTitle\">\u514d\u75ab\u6aa2\u67e5\u9ede<\/h4>\n\n\n\n<p>\u514d\u75ab\u7cfb\u7d71\u7684\u529f\u80fd\u4e3b\u8981\u662f\u4fdd\u8b77\u4eba\u9ad4\u514d\u53d7\u5916\u4f86\u5fae\u751f\u7269\u7684\u4fb5\u8972\uff0c\u95dc\u9375\u904e\u7a0b\u5728\u65bc\u5982\u4f55\u8fa8\u8b58\u8207\u5340\u5206\u300c\u81ea\u6211\u300d\u8207\u300c\u975e\u81ea\u6211\u300d\u5206\u5b50\uff0c\u9032\u800c\u4fc3\u6210\u91cd\u8981\u7684T\u6dcb\u5df4\u7d30\u80de\u6d3b\u5316\u3002\u800cT\u7d30\u80de\u6d3b\u5316\u904e\u7a0b\u5247\u4ef0\u8cf4\u6297\u539f\u5448\u73fe\u7d30\u80de\uff08antigen presenting cells\uff09\uff0c\u5c07\u6297\u539f\u6d88\u5316\u518d\u91cd\u65b0\u7d44\u88dd\u6210\u8b93T\u7d30\u80de\u53ef\u4ee5\u8b58\u5225\u7684\u578b\u614b\uff0c\u4e26\u53d7\u5230T\u7d30\u80de\u548c\u6297\u539f\u5448\u73fe\u7d30\u80de\u4e0a\u5206\u5b50\u7684\u7cbe\u5bc6\u8abf\u63a7\uff0c\u800c\u9019\u4e9b\u5206\u5b50\u5373\u7a31\u70ba\u514d\u75ab\u6aa2\u67e5\u9ede\uff08immune checkpoint\uff09\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image is-resized\"><img decoding=\"async\" src=\"https:\/\/cancer.lifeclinic.com.hk\/wp-content\/uploads\/2019\/12\/nobleprize2018_03.jpg\" alt=\"\" width=\"268\" height=\"251\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-embed-youtube wp-block-embed is-type-video is-provider-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"Announcement of the Nobel Prize in Physiology or Medicine 2018\" width=\"525\" height=\"295\" src=\"https:\/\/www.youtube.com\/embed\/gqwFR5AmpZ4?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>\u5728\u9019\u4e9b\u5206\u5b50\u4e2d\uff0c\u6709\u4e9b\u6703\u4fc3\u9032T\u7d30\u80de\u6d3b\u5316\uff0c\u523a\u6fc0\u514d\u75ab\u53cd\u61c9\u7684\u767c\u751f\uff0c\u4ee5\u78ba\u4fdd\u514d\u75ab\u7cfb\u7d71\u8db3\u4ee5\u5c0d\u6297\u5165\u4fb5\u7684\u75c5\u539f\u9ad4\uff1b\u6709\u4e9b\u5247\u6703\u6291\u5236\u6d3b\u5316\u8a0a\u865f\uff0c\u626e\u6f14\u6291\u5236\u89d2\u8272\u3001\u907f\u514d\u514d\u75ab\u7cfb\u7d71\u904e\u5ea6\u6d3b\u5316\u800c\u9020\u6210\u7d44\u7e54\u50b7\u5bb3\u4e4b\u865e\u3002\u4e8b\u5be6\u4e0a\uff0c\u514d\u75ab\u6aa2\u67e5\u9ede\u5e38\u88ab\u8996\u70ba\u514d\u75ab\u7cfb\u7d71\u4e2d\u6291\u5236\u578b\u7684\u8abf\u63a7\u5206\u5b50\uff0c\u5728\u514d\u75ab\u53cd\u61c9\u767c\u751f\u6642\u50b3\u905e\u6291\u5236\u8a0a\u865f\uff0c\u4ee5\u907f\u514d\u6216\u6e1b\u5c11\u7d44\u7e54\u640d\u50b7\uff0c\u7dad\u6301\u4e0d\u5f71\u97ff\u81ea\u8eab\u7d44\u7e54\u7d30\u80de\u7684\u81ea\u6211\u8010\u53d7\u6027\uff08self-tolerance\uff09\u3002<\/p>\n\n\n\n<ul class=\"wp-block-gallery columns-1 is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\"><li class=\"blocks-gallery-item\"><figure><img decoding=\"async\" width=\"1024\" height=\"712\" src=\"http:\/\/marseille-quince.com\/wp-content\/uploads\/2024\/05\/ch-research02.png\" alt=\"\" data-id=\"1413\" data-link=\"https:\/\/marseille-quince.com\/latest-research\/attachment\/research1\/\" class=\"wp-image-1413\" srcset=\"https:\/\/marseille-quince.com\/wp-content\/uploads\/2024\/05\/ch-research02.png 922w, https:\/\/marseille-quince.com\/wp-content\/uploads\/2024\/05\/ch-research02-350x245.png 350w, https:\/\/marseille-quince.com\/wp-content\/uploads\/2024\/05\/ch-research02-300x210.png 300w, https:\/\/marseille-quince.com\/wp-content\/uploads\/2024\/05\/ch-research02-768x538.png 768w, https:\/\/marseille-quince.com\/wp-content\/uploads\/2024\/05\/ch-research02-18x12.png 18w\" sizes=\"(max-width: 767px) 89vw, (max-width: 1000px) 54vw, (max-width: 1071px) 543px, 580px\" \/><\/figure><\/li><\/ul>\n\n\n\n<p>\u5716\u4e00\uff1a\u5728\u816b\u7624\u74b0\u5883\u53ca\u514d\u75ab\u6aa2\u67e5\u9ede\u7642\u6cd5\u4e2d\uff0c\u53c3\u8207\u6297\u816b\u7624\u514d\u75ab\u7684T\u7d30\u80de\u7684\u793a\u610f\u5716\u3002\u986f\u793aT\u7d30\u80de\u4e0aCD28\u3001CTLA-4\u548cPD-1\u8207\u6297\u539f\u5448\u73fe\u7d30\u80de\u548c\u816b\u7624\u4e0a\u7684\u914d\u9ad4\u4e4b\u9593\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u5728CTLA-4\u6297\u9ad4\u548cPD-1\uff08PD-L1\uff09\u6297\u9ad4\u5b58\u5728\u4e0b\uff0c\u6291\u5236T\u7d30\u80de\u6d3b\u5316\u7684\u4fe1\u865f\u88ab \u963b\u65b7\uff0c\u800c\u53cd\u904e\u4f86\u589e\u5f37T\u7d30\u80de\u6d3b\u5316\u4e26\u96a8\u5f8c\u589e\u5f37\u6297\u816b\u7624\u7684\u514d\u75ab\u53cd\u61c9\u3002<\/p>\n\n\n\n<p>1995\u5e74\uff0c\u827e\u5229\u68ee\u7814\u7a76\u767c\u73fe\u4e86\u7d30\u80de\u6bd2\u6027T\u6dcb\u5df4\u7d30\u80de\u6297\u539f4\uff08cytotoxic T-lymphocyte-associated protein 4, CTLA-4\uff09\u53ef\u6291\u5236T\u7d30\u80de\u6d3b\u5316\uff0c\u4e26\u8b49\u660eCTLA-4\u7684\u6297\u9ad4\u53ef\u4ee5\u963b\u65b7\u6291\u5236T\u7d30\u80de\u6d3b\u5316\u7684\u8a0a\u606f\u50b3\u905e\uff0c\u5c0e\u81f4T\u7d30\u80de\u6d3b\u5316\u4e26\u9032\u884c\u764c\u7d30\u80de\u7684\u6bd2\u6bba\u3002\u672c\u5eb6\u4f51\u6559\u6388\u5247\u65bc1992\u5e74\u767c\u73fe\u8a08\u756b\u6027\u6b7b\u4ea1\u86cb\u767d\u8cea-1\uff08programmed cell death protein 1, PD-1\uff09\u4f4d\u65bcT\u7d30\u80de\u4e0a\uff0c\u7576\u5176\u8a0a\u606f\u50b3\u905e\u6642\u6703\u8a98\u767c\u7a0b\u5e8f\u6027\u7684\u7d30\u80de\u6b7b\u4ea1\u53cd\u61c9\uff0c\u4e26\u8b49\u5be6\u5176\u5728\u816b\u7624\u9003\u907f\u6bd2\u6bba\u6a5f\u5236\u4e0a\u626e\u6f14\u8457\u95dc\u9375\u89d2\u8272\u3002\u4e0a\u8ff0\u5169\u8005\u7684\u6297\u9ad4\u85e5\u7269\u9678\u7e8c\u88ab\u7814\u767c\uff0c\u4e26\u7d93\u81e8\u5e8a\u8a66\u9a57\u8b49\u660e\u55ae\u4e00\u6216\u5408\u4f75\u4f7f\u7528\u6297CTLA-4\u6297\u9ad4\u53ca\u6297PD-1\u6297\u9ad4\u53ef\u6bba\u6b7b\u764c\u7d30\u80de\uff0c\u80fd\u6cbb\u7642\u764c\u75c7\u4e26\u986f\u8457\u5ef6\u9577\u90e8\u5206\u60a3\u8005\u7684\u751f\u547d\u3002 2\u4eba\u4e5f\u56e0\u5f15\u9818\u764c\u75c7\u6cbb\u7642\u9032\u5165\u5168\u65b0\u7d00\u5143\uff0c\u66fe\u65bc2014\u5e74\u7372\u5f97\u7531\u5c39\u884d\u6a11\u535a\u58eb\u6240\u8a2d\u7acb\u7684\u7b2c\u4e00\u5c46\u5510\u734e\uff08Tang Prize\uff09\u751f\u6280\u91ab\u85e5\u734e\u3002<br><\/p>","protected":false},"excerpt":{"rendered":"<p>Nobel Prize in Medicine-Cancer Immunotherapy Identify immune system signals to suppress and focus on attacking tumors The 2018 Nobel Prize in Physiology or Medicine was awarded to James P. Allison of The University of Texas M. D. Anderson Cancer Center (UT MDA) and Tasuku Honjo of Kyoto University, Japan. (Tasuku Honjo) shared the award, and &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/marseille-quince.com\/zh\/latest-research\/\" class=\"more-link\">\u7e7c\u7e8c\u95b1\u8b80<span class=\"screen-reader-text\"> &#8220;Research Update&#8221;<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"footnotes":""},"class_list":["post-1315","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/pages\/1315","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/comments?post=1315"}],"version-history":[{"count":3,"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/pages\/1315\/revisions"}],"predecessor-version":[{"id":1414,"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/pages\/1315\/revisions\/1414"}],"wp:attachment":[{"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/media?parent=1315"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}