{"id":2032,"date":"2025-12-28T10:40:59","date_gmt":"2025-12-28T10:40:59","guid":{"rendered":"https:\/\/marseille-quince.com\/?page_id=2032"},"modified":"2026-01-07T16:06:55","modified_gmt":"2026-01-07T08:06:55","slug":"about-nmn","status":"publish","type":"page","link":"https:\/\/marseille-quince.com\/zh\/about-nmn\/","title":{"rendered":"\u95dc\u65bcNMN"},"content":{"rendered":"<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/static.wixstatic.com\/media\/55242c_25230b3939e3446dac74ad30d78210a1~mv2.jpg\/v1\/fill\/w_939,h_622,al_c,q_85,usm_0.66_1.00_0.01,enc_auto\/pexels-polina-tankilevitch-3735782.jpg\" alt=\"pexels-polina-tankilevitch-3735782.jpg\"\/><\/figure>\n\n\n\n<h1 class=\"wp-block-heading\"><strong>\u4ec0\u9ebc\u662f NMN\uff1f<\/strong><\/h1>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/static.wixstatic.com\/media\/55242c_bcbabf3e323044239cfa07d69759cc14~mv2.jpg\/v1\/fill\/w_836,h_454,al_c,q_85,usm_0.66_1.00_0.01,enc_auto\/nmn1.jpg\" alt=\"nmn1.jpg\"\/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4ec0\u9ebc\u662f NMN\uff1f<\/strong><\/h2>\n\n\n\n<p>NMN \u4ee3\u8868&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Nicotinamide_mononucleotide\" target=\"_blank\" rel=\"noreferrer noopener\">\u7159\u9170\u80fa\u55ae\u6838\u82f7\u9178\uff0c<\/a>\u4e00\u7a2e\u5929\u7136\u5b58\u5728\u65bc\u6240\u6709\u751f\u547d\u5f62\u5f0f\u4e2d\u7684\u5206\u5b50\u3002\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\uff0c\u5b83\u662f\u4e00\u7a2e\u6838\u7cd6\u6838\u82f7\u9178\uff0c\u662f\u6838\u9178RNA\u7684\u57fa\u672c\u7d50\u69cb\u55ae\u5143\u3002\u5728\u7d50\u69cb\u4e0a\uff0c\u8a72\u5206\u5b50\u7531\u7159\u9170\u80fa\u57fa\u5718\u3001\u6838\u7cd6\u548c\u78f7\u9178\u57fa\u5718\u7d44\u6210\uff08\u5716 1\uff09\u3002 NMN \u662f\u5fc5\u9700\u5206\u5b50\u7159\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+) \u7684\u76f4\u63a5\u524d\u9ad4\uff0c\u88ab\u8a8d\u70ba\u662f\u63d0\u9ad8\u7d30\u80de\u4e2d NAD+ \u6c34\u5e73\u7684\u95dc\u9375\u6210\u5206\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4ec0\u9ebc\u662f\u7159\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+)\uff1f<\/strong><\/h2>\n\n\n\n<p>NAD+ \u662f\u751f\u547d\u548c\u7d30\u80de\u529f\u80fd\u6240\u9700\u7684\u5fc5\u9700\u8f14\u9176\u3002\u9176\u662f\u4f7f\u751f\u5316\u53cd\u61c9\u6210\u70ba\u53ef\u80fd\u7684\u50ac\u5316\u5291\u3002\u8f14\u9176\u662f\u9176\u767c\u63ee\u529f\u80fd\u6240\u9700\u7684\u201c\u8f14\u52a9\u201d\u5206\u5b50\u3002&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>NAD+\u6709\u4ec0\u9ebc\u4f5c\u7528\uff1f<\/strong><\/h2>\n\n\n\n<p>NAD+ \u662f\u9ad4\u5167\u9664\u6c34\u4e4b\u5916\u6700\u8c50\u5bcc\u7684\u5206\u5b50\uff0c\u6c92\u6709\u5b83\uff0c\u751f\u7269\u9ad4\u5c31\u6703\u6b7b\u4ea1\u3002 NAD+ \u88ab\u5168\u8eab\u7684\u8a31\u591a\u86cb\u767d\u8cea\u4f7f\u7528\uff0c\u4f8b\u5982\u4fee\u5fa9\u53d7\u640d DNA \u7684 Sirtuins\u3002\u5b83\u5c0d\u7dda\u7c92\u9ad4\u4e5f\u5f88\u91cd\u8981\uff0c\u7dda\u7c92\u9ad4\u662f\u7d30\u80de\u7684\u52d5\u529b\u6e90\uff0c\u7522\u751f\u6211\u5011\u8eab\u9ad4\u4f7f\u7528\u7684\u5316\u5b78\u80fd\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>NAD+ \u5728\u7dda\u7c92\u9ad4\u4e2d\u4f5c\u70ba\u8f14\u9176\u767c\u63ee\u4f5c\u7528<\/strong><\/h3>\n\n\n\n<p>NAD+ \u5728\u4ee3\u8b1d\u904e\u7a0b\u4e2d\u767c\u63ee\u8457\u7279\u5225\u7a4d\u6975\u7684\u4f5c\u7528\uff0c\u4f8b\u5982\u7cd6\u9175\u89e3\u3001TCA \u5faa\u74b0\uff08\u53c8\u540d\u4e09\u7fa7\u9178\u5faa\u74b0\u6216\u6ab8\u6aac\u9178\u5faa\u74b0\uff09\u548c\u96fb\u5b50\u50b3\u905e\u93c8\uff0c\u5b83\u767c\u751f\u5728\u6211\u5011\u7684\u7dda\u7c92\u9ad4\u4e2d\uff0c\u662f\u6211\u5011\u7372\u53d6\u7d30\u80de\u80fd\u91cf\u7684\u65b9\u5f0f\u3002<\/p>\n\n\n\n<p>\u4f5c\u70ba\u914d\u9ad4\uff0cNAD+ \u8207\u9176\u7d50\u5408\u4f75\u5728\u5206\u5b50\u4e4b\u9593\u8f49\u79fb\u96fb\u5b50\u3002\u96fb\u5b50\u662f\u7d30\u80de\u80fd\u91cf\u7684\u539f\u5b50\u57fa\u790e\uff0c\u901a\u904e\u5c07\u5b83\u5011\u5f9e\u4e00\u500b\u5206\u5b50\u8f49\u79fb\u5230\u53e6\u4e00\u500b\u5206\u5b50\uff0cNAD+ \u901a\u904e\u985e\u4f3c\u65bc\u7d66\u96fb\u6c60\u5145\u96fb\u7684\u7d30\u80de\u6a5f\u5236\u8d77\u4f5c\u7528\u3002\u7576\u6d88\u8017\u96fb\u5b50\u4f86\u63d0\u4f9b\u80fd\u91cf\u6642\uff0c\u96fb\u6c60\u5c31\u6703\u8017\u76e1\u3002\u90a3\u4e9b\u96fb\u5b50\u5728\u6c92\u6709\u63d0\u5347\u7684\u60c5\u6cc1\u4e0b\u7121\u6cd5\u8fd4\u56de\u5230\u5b83\u5011\u7684\u8d77\u9ede\u3002\u5728\u7d30\u80de\u4e2d\uff0cNAD+ \u5145\u7576\u52a9\u63a8\u5668\u3002\u901a\u904e\u9019\u7a2e\u65b9\u5f0f\uff0cNAD+ \u53ef\u4ee5\u964d\u4f4e\u6216\u589e\u52a0\u9176\u6d3b\u6027\u3001\u57fa\u56e0\u8868\u9054\u548c\u7d30\u80de\u4fe1\u865f\u3002&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>NAD+ \u6709\u52a9\u65bc\u63a7\u5236 DNA \u640d\u50b7<\/strong><\/h3>\n\n\n\n<p>\u96a8\u8457\u751f\u7269\u9ad4\u5e74\u9f61\u7684\u589e\u9577\uff0c\u7531\u65bc\u8f3b\u5c04\u3001\u6c61\u67d3\u548c\u4e0d\u7cbe\u78ba\u7684 DNA \u8907\u88fd\u7b49\u74b0\u5883\u56e0\u7d20\uff0c\u5b83\u5011\u6703\u7522\u751f DNA \u640d\u50b7\u3002\u6839\u64da\u76ee\u524d\u7684\u8870\u8001\u7406\u8ad6\uff0cDNA\u640d\u50b7\u7684\u7a4d\u7d2f\u662f\u5c0e\u81f4\u8870\u8001\u7684\u4e3b\u8981\u539f\u56e0\u3002\u5e7e\u4e4e\u6240\u6709\u7d30\u80de\u90fd\u542b\u6709\u4fee\u5fa9\u9019\u7a2e\u640d\u50b7\u7684\u201c\u5206\u5b50\u6a5f\u5668\u201d\u3002\u9019\u7a2e\u6a5f\u5668\u6d88\u8017 NAD+ \u548c\u80fd\u91cf\u5206\u5b50\u3002\u56e0\u6b64\uff0c\u904e\u5ea6\u7684 DNA \u640d\u50b7\u6703\u8017\u76e1\u5bf6\u8cb4\u7684\u7d30\u80de\u8cc7\u6e90\u3002<\/p>\n\n\n\n<p>\u96a8\u8457\u751f\u7269\u9ad4\u5e74\u9f61\u7684\u589e\u9577\uff0c\u7531\u65bc\u8f3b\u5c04\u3001\u6c61\u67d3\u548c\u4e0d\u7cbe\u78ba\u7684 DNA \u8907\u88fd\u7b49\u74b0\u5883\u56e0\u7d20\uff0c\u5b83\u5011\u6703\u7522\u751f DNA \u640d\u50b7\u3002\u6839\u64da\u76ee\u524d\u7684\u8870\u8001\u7406\u8ad6\uff0c&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29342113\" target=\"_blank\" rel=\"noreferrer noopener\">DNA\u640d\u50b7\u7684\u7a4d\u7d2f\u662f\u5c0e\u81f4\u8870\u8001\u7684\u4e3b\u8981\u539f\u56e0\u3002<\/a>\u5e7e\u4e4e\u6240\u6709\u7d30\u80de\u90fd\u542b\u6709\u4fee\u5fa9\u9019\u7a2e\u640d\u50b7\u7684\u201c\u5206\u5b50\u6a5f\u5668\u201d\u3002\u9019\u7a2e\u6a5f\u5668\u6d88\u8017 NAD+ \u548c\u80fd\u91cf\u5206\u5b50\u3002\u56e0\u6b64\uff0c\u904e\u5ea6\u7684 DNA \u640d\u50b7\u6703\u8017\u76e1\u5bf6\u8cb4\u7684\u7d30\u80de\u8cc7\u6e90\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>PARP1\u662fDNA\u4fee\u5fa9\u7684\u201c\u4e2d\u9593\u4eba\u201d<\/strong><\/h2>\n\n\n\n<p><video src=\"https:\/\/www.wellixx.com\/wp-content\/uploads\/2024\/06\/parp-2.mp4\"><\/video><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>PARP1 \u5982\u4f55\u5e6b\u52a9\u4fee\u5fa9\u53d7\u640d DNA \u7684\u793a\u610f\u5716<\/strong><\/h2>\n\n\n\n<p><video controls=\"\" src=\"https:\/\/www.wellixx.com\/wp-content\/uploads\/2024\/06\/parp-3.mp4\"><\/video><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>NAD+ \u5982\u4f55\u5f71\u97ff Sirtuins\uff08\u9577\u58fd\u57fa\u56e0\uff09\u6d3b\u6027\uff1f<\/strong><\/h3>\n\n\n\n<p><video controls=\"\" src=\"https:\/\/www.wellixx.com\/wp-content\/uploads\/2024\/06\/sirt4.webm\"><\/video><\/p>\n\n\n\n<p>\u65b0\u767c\u73fe\u7684sirtuins\uff0c\u4e5f\u88ab\u7a31\u70ba\u201c\u57fa\u56e0\u7684\u5b88\u8b77\u8005\u201d\uff0c\u5728\u7dad\u6301\u7d30\u80de\u5065\u5eb7\u65b9\u9762\u767c\u63ee\u8457\u81f3\u95dc\u91cd\u8981\u7684\u4f5c\u7528\u3002 Sirtuins \u662f\u4e00\u500b\u9176\u5bb6\u65cf\uff0c\u53c3\u8207\u7d30\u80de\u61c9\u6fc0\u53cd\u61c9\u548c\u640d\u50b7\u4fee\u5fa9\u3002\u5b83\u5011\u9084\u53c3\u8207\u80f0\u5cf6\u7d20\u5206\u6ccc\u3001\u8870\u8001\u904e\u7a0b\u548c\u8207\u8870\u8001\u76f8\u95dc\u7684\u5065\u5eb7\u72c0\u6cc1\uff0c\u5982\u795e\u7d93\u9000\u884c\u6027\u75be\u200b\u200b\u75c5\u548c\u7cd6\u5c3f\u75c5\u3002 Sirtuins \u7684\u6fc0\u6d3b\u9700\u8981 NAD+\u3002&nbsp;<\/p>\n\n\n\n<p>\u6b63\u5982\u54c8\u4f5b\u5927\u5b78\u907a\u50b3\u5b78\u5bb6\u548c NAD \u7814\u7a76\u4eba\u54e1\u5927\u885b\u8f9b\u514b\u840a\u6240\u8aaa\uff0c\u96a8\u8457\u5e74\u9f61\u7684\u589e\u9577\uff0c\u6211\u5011\u6703\u5931\u53bb NAD+\uff0c\u201c\u7531\u6b64\u5c0e\u81f4\u7684\u6c89\u9ed8\u8abf\u7bc0\u86cb\u767d\u6d3b\u6027\u4e0b\u964d\uff0c\u88ab\u8a8d\u70ba\u662f\u6211\u5011\u7684\u8eab\u9ad4\u5728\u5e74\u8001\u6642\u6703\u751f\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u4f46\u5728\u6211\u5011\u5e74\u8f15\u6642\u4e0d\u6703\u3002\u201d\u4ed6\u8a8d\u70ba\uff0c\u5728\u8870\u8001\u904e\u7a0b\u4e2d\u81ea\u7136\u589e\u52a0 NAD+ \u6c34\u5e73\u53ef\u80fd\u6703\u6e1b\u7de9\u6216\u9006\u8f49\u67d0\u4e9b\u8870\u8001\u904e\u7a0b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u6211\u5011\u70ba\u4ec0\u9ebc\u8981\u95dc\u5fc3 NAD+<\/strong><\/h2>\n\n\n\n<p>\u81ea 1906 \u5e74\u767c\u73fe NAD+ \u4ee5\u4f86\uff0c\u8a72\u5206\u5b50\u56e0\u5176\u5728\u9ad4\u5167\u7684\u8c50\u5ea6\u53ca\u5176\u5728\u4fdd\u6301\u6211\u5011\u8eab\u9ad4\u904b\u8f49\u7684\u5206\u5b50\u9014\u5f91\u4e2d\u7684\u95dc\u9375\u4f5c\u7528\u800c\u53d7\u5230\u79d1\u5b78\u5bb6\u5011\u7684\u95dc\u6ce8\u3002\u5728\u52d5\u7269\u7814\u7a76\u4e2d\uff0c\u63d0\u9ad8\u9ad4\u5167 NAD+ \u6c34\u5e73\u5728\u4ee3\u8b1d\u548c\u5e74\u9f61\u76f8\u95dc\u75be\u75c5\u7b49\u7814\u7a76\u9818\u57df\u986f\u793a\u51fa\u53ef\u559c\u7684\u6210\u679c\uff0c\u751a\u81f3\u986f\u793a\u51fa\u4e00\u4e9b\u6297\u8870\u8001\u7279\u6027\u3002\u8207\u5e74\u9f61\u76f8\u95dc\u7684\u75be\u75c5\uff0c\u5982\u7cd6\u5c3f\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u795e\u7d93\u9000\u884c\u6027\u75be\u200b\u200b\u75c5\u548c\u514d\u75ab\u7cfb\u7d71\u666e\u904d\u4e0b\u964d\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>NMN \u53ef\u4ee5\u5e6b\u52a9\u5c0d\u6297 COVID-19<\/strong><\/h3>\n\n\n\n<p>\u96a8\u8457 COVID-19 \u4ee5\u985e\u4f3c\u80ba\u708e\u7684\u75be\u75c5\u5e2d\u6372\u57ce\u5e02\uff0c\u611f\u67d3\u4e86\u5168\u7403\u6578\u767e\u842c\u4eba\uff0c\u79d1\u5b78\u5bb6\u5011\u6b63\u5728\u5c0b\u627e\u5b89\u5168\u6709\u6548\u7684\u6cbb\u7642\u65b9\u6cd5\u3002 Gerontologist \u662f\u7814\u7a76\u8870\u8001\u751f\u7269\u5b78\u7684\u79d1\u5b78\u5bb6\uff0c\u4ed6\u5011\u8a8d\u70ba\u91dd\u5c0d\u8870\u8001\u7684\u7642\u6cd5\u53ef\u80fd\u6703\u63d0\u4f9b\u4e00\u500b\u65b0\u7684\u89d2\u5ea6\u4f86\u61c9\u5c0d\u9019\u4e00\u6d41\u884c\u75c5\u3002<\/p>\n\n\n\n<p>\u7d71\u8a08\u6578\u64da\u986f\u793a\uff0cCOVID-19 \u4e0d\u6210\u6bd4\u4f8b\u5730\u611f\u67d3\u8001\u5e74\u4eba\u3002\u5728 80 \u6b72\u6216\u4ee5\u4e0a\u7684\u60a3\u8005\u4e2d\uff0c&nbsp;<a href=\"https:\/\/www.thelancet.com\/journals\/laninf\/article\/PIIS1473-3099(20)30243-7\/fulltext\" target=\"_blank\" rel=\"noreferrer noopener\">\u7d04\u6709 13.4% \u6b7b\u65bc COVID-19\uff0c<\/a>&nbsp;\u800c\u5728 50 \u591a\u6b72\u548c 20 \u591a\u6b72\u7684\u60a3\u8005\u4e2d\uff0c\u9019\u4e00\u6bd4\u4f8b\u5206\u5225\u70ba 1.25% \u548c 0.06%\u3002\u725b\u6d25\u5927\u5b78\u6700\u8fd1\u7684\u4e00\u9805\u5206\u6790\u4e86 1740 \u842c\u82f1\u570b\u6210\u5e74\u4eba\u7684\u7814\u7a76\u8868\u660e\uff0c&nbsp;<a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2020.05.06.20092999v1\" target=\"_blank\" rel=\"noreferrer noopener\">\u5e74\u9f61\u662f\u8207 COVID-19 \u6b7b\u4ea1\u76f8\u95dc\u7684\u6700\u91cd\u8981\u7684\u98a8\u96aa\u56e0\u7d20\u3002<\/a>&nbsp;\u5176\u4ed6\u98a8\u96aa\u56e0\u7d20\u5305\u62ec\u7537\u6027\u3001\u4e0d\u53d7\u63a7\u5236\u7684\u7cd6\u5c3f\u75c5\u548c\u56b4\u91cd\u7684\u54ee\u5598\u3002<\/p>\n\n\n\n<p>\u9451\u65bc\u8a72\u75c5\u6bd2\u5c0d\u8001\u5e74\u4eba\u6709\u5bb3\uff0c\u4e00\u4e9b\u8001\u5e74\u75c5\u5b78\u5bb6\u8072\u7a31 \uff0c&nbsp;<a href=\"https:\/\/www.nmn.com\/news\/treating-aging-overcome-covid-19\" target=\"_blank\" rel=\"noreferrer noopener\">\u6cbb\u7642\u201c\u8870\u8001\u201d\u53ef\u80fd\u662f\u4fdd\u8b77\u8001\u5e74\u4eba\u514d\u53d7 COVID-19 \u548c\u5176\u4ed6\u672a\u4f86\u50b3\u67d3\u75c5\u7684\u9577\u671f\u89e3\u6c7a\u65b9\u6848\u3002<\/a>&nbsp;\u5118\u7ba1\u9700\u8981\u505a\u66f4\u591a\u7684\u7814\u7a76\uff0c&nbsp;<a href=\"https:\/\/www.aging-us.com\/article\/102988\/text\" target=\"_blank\" rel=\"noreferrer noopener\">\u4f46\u6700\u8fd1\u7684\u4e00\u9805\u7814\u7a76<\/a>&nbsp;\u5c07 NMN \u548c NR\u7b49 NAD+&nbsp;<a href=\"https:\/\/www.nmn.com\/precursors\/nmn-vs-nr\" target=\"_blank\" rel=\"noreferrer noopener\">NMN and NR<\/a>&nbsp;\u4fc3\u9032\u5291\u5217\u70ba\u6f5b\u5728\u7684\u6cbb\u7642\u65b9\u6cd5\u4e4b\u4e00\u3002\u5176\u4ed6\u79d1\u5b78\u5bb6\u9084&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1876034120304986#!\" target=\"_blank\" rel=\"noreferrer noopener\">\u5047\u8a2d<\/a>&nbsp;\uff0c\u8001\u5e74\u4eba\u53ef\u80fd\u53d7\u76ca\u65bc NAD+ \u7684\u9577\u58fd\u6548\u61c9\uff0c\u4e26\u9632\u6b62\u7a31\u70ba\u7d30\u80de\u56e0\u5b50\u98a8\u66b4\u7684\u514d\u75ab\u53cd\u61c9\u7684\u81f4\u547d\u904e\u5ea6\u6fc0\u6d3b\uff0c\u5728\u9019\u7a2e\u60c5\u6cc1\u4e0b\uff0c\u8eab\u9ad4\u6703\u653b\u64ca\u5176\u7d30\u80de\u800c\u4e0d\u662f\u75c5\u6bd2\u3002<\/p>\n\n\n\n<p>\u6839\u64da\u6700\u8fd1\u7684\u4e00\u9805\u672a\u7d93\u540c\u884c\u8a55\u5be9\u7684\u7814\u7a76\uff0c&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7217258\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u7d30\u80de\u5728\u5c0d\u6297\u51a0\u72c0\u75c5\u6bd2\u7684\u904e\u7a0b\u4e2d\u6703\u6d88\u8017 NAD+\uff0c<\/a>&nbsp;\u5f9e\u800c\u524a\u5f31\u6211\u5011\u7684\u8eab\u9ad4\u3002 NAD+ \u5c0d\u65bc\u91dd\u5c0d\u75c5\u6bd2\u7684\u5148\u5929\u514d\u75ab\u9632\u79a6\u81f3\u95dc\u91cd\u8981\u3002\u8a72\u7814\u7a76\u7684\u7814\u7a76\u4eba\u54e1\u6b63\u8a66\u5716\u8a55\u4f30 NAD+ \u52a9\u63a8\u5668\u662f\u5426\u53ef\u4ee5\u5e6b\u52a9\u4eba\u985e\u6230\u52dd\u5927\u6d41\u884c\u3002<\/p>\n\n\n\n<p>\u7576\u79d1\u5b78\u5bb6\u5011\u5728\u5be6\u9a57\u5ba4\u88e1\u722d\u5206\u596a\u79d2\u5730\u5c0b\u627e\u6cbb\u7642 COVID-19 \u7684\u65b9\u6cd5\u6642\uff0c\u524d\u7dda\u7684\u91ab\u751f\u6c92\u6709\u9078\u64c7\u7684\u9918\u5730\u8f49\u5411\u5275\u65b0\u6280\u8853\u3002\u4f5c\u70ba\u6cbb\u7642\u60a3\u8005\u7684\u6700\u5f8c\u624b\u6bb5\uff0cCedars Sinai \u91ab\u7642\u4e2d\u5fc3\u7684\u91ab\u751f Robert Huizenga \u7d66\u60a3\u8005\u8a3b\u5c04\u4e86\u4e00\u7a2e&nbsp;<a href=\"https:\/\/www.nmn.com\/news\/covid-19-patients-nmn-treatment\" target=\"_blank\" rel=\"noreferrer noopener\">NMN \u96de\u5c3e\u9152<\/a>&nbsp;\uff0c\u5176\u4e2d\u8a3b\u5165\u4e86\u92c5\u7b49\u52a9\u63a8\u5668\uff0c \u4ee5\u5e73\u606f COVID-19 \u5f15\u767c\u7684\u7d30\u80de\u56e0\u5b50\u98a8\u66b4\u3002 NMN \u96de\u5c3e\u9152\u5728 12 \u5c0f\u6642\u5167\u964d\u4f4e\u4e86\u60a3\u8005\u7684\u767c\u71d2\u548c\u708e\u75c7\u6c34\u5e73\u3002<\/p>\n\n\n\n<p>\u5728\u5927\u6d41\u884c\u671f\u9593\uff0cNMN\u56e0\u5176\u5728\u7dad\u6301\u514d\u75ab\u7cfb\u7d71\u5e73\u8861\u65b9\u9762\u7684\u4f5c\u7528\u800c\u53d7\u5230\u8d8a\u4f86\u8d8a\u591a\u7684\u95dc\u6ce8\uff0c\u9019\u53ef\u80fd\u662f\u51a0\u72c0\u75c5\u6bd2\u5f15\u8d77\u7684\u7d30\u80de\u56e0\u5b50\u98a8\u66b4\u7684\u4e00\u7a2e\u53ef\u80fd\u7684\u6cbb\u7642\u65b9\u6cd5\u3002\u521d\u6b65\u7814\u7a76\u986f\u793a\u4e86\u4e00\u4e9b\u7a4d\u6975\u7684\u7d50\u679c\uff0c\u96d6\u7136\u4e0d\u80fd\u4fdd\u8b49\u6cbb\u6108\uff0c\u4f46\u8a31\u591a\u79d1\u5b78\u5bb6\u548c\u91ab\u751f\u8a8d\u70ba NAD+ \u52a9\u63a8\u5668\u5c0d COVID-19 \u7684\u5f71\u97ff\u503c\u5f97\u7814\u7a76\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u8870\u8001<\/strong><\/h3>\n\n\n\n<p>NAD+ \u662f\u5e6b\u52a9&nbsp;<a href=\"https:\/\/www.nmn.com\/news\/nmn-supplementation-may-improve-conditions-associated-with-reduced-dna-integrity\" target=\"_blank\" rel=\"noreferrer noopener\">Sirtuins \u7dad\u6301\u57fa\u56e0\u7d44\u5b8c\u6574\u6027\u548c\u4fc3\u9032 DNA \u4fee\u5fa9\u7684\u71c3\u6599\u3002<\/a>\u5c31\u50cf\u6c7d\u8eca\u4e0d\u80fd\u5728\u6c92\u6709\u71c3\u6599\u7684\u60c5\u6cc1\u4e0b\u884c\u99db\u4e00\u6a23\uff0csirtuins \u7684\u6fc0\u6d3b\u9700\u8981 NAD+\u3002\u52d5\u7269\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0c\u63d0\u9ad8\u9ad4\u5167 NAD+ \u6c34\u5e73\u6703\u6fc0\u6d3b Sirtuins\uff0c\u4e26\u5ef6\u9577\u9175\u6bcd\u3001\u8815\u87f2\u548c\u5c0f\u9f20\u7684\u58fd\u547d\u3002\u5118\u7ba1\u52d5\u7269\u7814\u7a76\u5728\u6297\u8870\u8001\u7279\u6027\u65b9\u9762\u986f\u793a\u51fa\u6709\u5e0c\u671b\u7684\u7d50\u679c\uff0c\u4f46\u79d1\u5b78\u5bb6\u5011\u4ecd\u5728\u7814\u7a76\u9019\u4e9b\u7d50\u679c\u5982\u4f55\u8f49\u5316\u70ba\u4eba\u985e\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u4ee3\u8b1d\u7d0a\u4e82<\/strong><\/h3>\n\n\n\n<p>NAD+ \u662f&nbsp;<a href=\"https:\/\/www.nmn.com\/news\/scientists-demonstrate-increasing-nad-levels-restores-mitochondrial-function-and-limits-aging\" target=\"_blank\" rel=\"noreferrer noopener\">\u7dad\u6301\u5065\u5eb7\u7dda\u7c92\u9ad4\u529f\u80fd<\/a>&nbsp;\u548c\u7a69\u5b9a\u80fd\u91cf\u8f38\u51fa\u7684\u95dc\u9375\u4e4b\u4e00\u3002\u8870\u8001\u548c\u9ad8\u8102\u80aa\u98f2\u98df\u6703\u964d\u4f4e\u9ad4\u5167 NAD+ \u7684\u6c34\u5e73\u3002\u7814\u7a76\u8868\u660e\uff0c\u670d\u7528 NAD+ \u589e\u5f37\u5291\u53ef\u4ee5\u6e1b\u8f15\u5c0f\u9f20\u8207\u98f2\u98df\u76f8\u95dc\u548c\u5e74\u9f61\u76f8\u95dc\u7684\u9ad4\u91cd\u589e\u52a0\uff0c\u4e26\u63d0\u9ad8\u5b83\u5011\u7684\u904b\u52d5\u80fd\u529b\uff0c\u5373\u4f7f\u662f\u8001\u5e74\u5c0f\u9f20\u4e5f\u662f\u5982\u6b64\u3002\u5176\u4ed6\u7814\u7a76\u751a\u81f3\u9006\u8f49\u4e86\u96cc\u6027\u5c0f\u9f20\u7684\u7cd6\u5c3f\u75c5\u6548\u61c9\uff0c\u5c55\u793a\u4e86\u5c0d\u6297\u80a5\u80d6\u7b49\u4ee3\u8b1d\u7d0a\u4e82\u7684\u65b0\u7b56\u7565\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u5fc3\u81df\u529f\u80fd<\/strong><\/h3>\n\n\n\n<p><a href=\"https:\/\/www.nmn.com\/news\/nmn-provides-heart-protection-in-mice\" target=\"_blank\" rel=\"noreferrer noopener\">\u63d0\u9ad8 NAD+ \u6c34\u5e73\u53ef\u4ee5\u4fdd\u8b77\u5fc3\u81df<\/a>&nbsp;\u4e26\u6539\u5584\u5fc3\u81df\u529f\u80fd\u3002\u9ad8\u8840\u58d3\u6703\u5c0e\u81f4\u5fc3\u81df\u64f4\u5927\u548c\u52d5\u8108\u963b\u585e\uff0c\u5f9e\u800c\u5c0e\u81f4\u4e2d\u98a8\u3002\u5728\u5c0f\u9f20\u4e2d\uff0cNAD+ \u52a9\u63a8\u5668\u88dc\u5145\u4e86\u5fc3\u81df\u4e2d\u7684 NAD+ \u6c34\u5e73\uff0c\u4e26\u9632\u6b62\u4e86\u56e0\u8840\u6d41\u4e0d\u8db3\u800c\u9020\u6210\u7684\u5fc3\u81df\u640d\u50b7\u3002\u5176\u4ed6\u7814\u7a76\u8868\u660e\uff0cNAD+ \u52a9\u63a8\u5668\u53ef\u4ee5\u4fdd\u8b77\u5c0f\u9f20\u514d\u53d7\u5fc3\u81df\u7570\u5e38\u589e\u5927\u7684\u5f71\u97ff\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u795e\u7d93\u8b8a\u6027<\/strong><\/h3>\n\n\n\n<p>\u5728\u60a3\u6709\u963f\u723e\u8328\u6d77\u9ed8\u6c0f\u75c7\u7684\u5c0f\u9f20\u4e2d\uff0c\u63d0\u9ad8 NAD+ \u6c34\u5e73\u53ef\u4ee5\u6e1b\u5c11\u86cb\u767d\u8cea\u7a4d\u805a\uff0c\u9019\u7a2e\u7a4d\u805a\u6703\u7834\u58de\u5927\u8166\u4e2d\u7684\u7d30\u80de\u901a\u8a0a\uff0c&nbsp;<a href=\"https:\/\/www.nmn.com\/news\/molecular-model-of-restoration-of-cognition-in-aging-with-nmn\" target=\"_blank\" rel=\"noreferrer noopener\">\u5f9e\u800c\u589e\u5f37\u8a8d\u77e5\u529f\u80fd\u3002<\/a>\u7576\u6d41\u5411\u5927\u8166\u7684\u8840\u6d41\u91cf\u4e0d\u8db3\u6642\uff0c\u63d0\u9ad8 NAD+ \u6c34\u5e73\u9084\u53ef\u4ee5\u4fdd\u8b77\u8166\u7d30\u80de\u514d\u65bc\u6b7b\u4ea1\u3002\u8a31\u591a\u52d5\u7269\u6a21\u578b\u7814\u7a76\u70ba\u5e6b\u52a9\u5927\u8166\u5065\u5eb7\u8001\u5316\u3001&nbsp;<a href=\"https:\/\/www.nmn.com\/news\/brian-dysfunctions-in-alzheimers-disease-decreased-linked-to-lower-nad-and-nmn-production-by-nampt-in-app-ps1-mice\" target=\"_blank\" rel=\"noreferrer noopener\">\u62b5\u5fa1\u795e\u7d93\u8b8a\u6027<\/a>&nbsp;\u548c&nbsp;<a href=\"https:\/\/www.nmn.com\/news\/nmn-and-melatonin-can-improve-memory-in-aged-rats\" target=\"_blank\" rel=\"noreferrer noopener\">\u63d0\u9ad8\u8a18\u61b6\u529b\u63d0\u4f9b\u4e86\u65b0\u7684\u524d\u666f\u3002.<\/a>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u514d\u75ab\u7cfb\u7d71<\/strong><\/h3>\n\n\n\n<p>\u96a8\u8457\u6210\u5e74\u4eba\u5e74\u9f61\u7684\u589e\u9577\uff0c&nbsp;<a href=\"https:\/\/www.nmn.com\/news\/treating-aging-overcome-covid-19\" target=\"_blank\" rel=\"noreferrer noopener\">\u514d\u75ab\u7cfb\u7d71\u6703\u4e0b\u964d\uff0c \u4eba\u5011\u66f4\u5bb9\u6613\u751f\u75c5\uff0c\u800c\u4e14\u4eba\u5011\u66f4\u96e3\u5f9e\u5b63\u7bc0\u6027\u6d41\u611f\u751a\u81f3 COVID-19\u7b49\u75be\u75c5\u4e2d\u6062\u5fa9\u904e\u4f86\u3002<\/a>\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0cNAD+ \u6c34\u5e73\u5728\u8abf\u7bc0\u514d\u75ab\u53cd\u61c9\u548c\u8870\u8001\u904e\u7a0b\u4e2d\u7684\u708e\u75c7\u548c\u7d30\u80de\u5b58\u6d3b\u65b9\u9762\u767c\u63ee\u8457\u91cd\u8981\u4f5c\u7528\u3002\u8a72\u7814\u7a76\u5f37\u8abf\u4e86 NAD+ \u5c0d\u514d\u75ab\u529f\u80fd\u969c\u7919\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u200b<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u8eab\u9ad4\u5982\u4f55\u88fd\u9020\u7159\u91af\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178 (NAD+)\uff1f<\/strong><\/h2>\n\n\n\n<p>\u6211\u5011\u7684\u8eab\u9ad4\u81ea\u7136\u6703\u5f9e\u8f03\u5c0f\u7684\u6210\u5206\u6216\u524d\u9ad4\u4e2d\u7522\u751f NAD+\u3002\u5c07\u5b83\u5011\u8996\u70ba NAD+ \u7684\u539f\u6750\u6599\u3002\u9ad4\u5167\u6709\u4e94\u7a2e\u4e3b\u8981\u524d\u9ad4\uff1a\u8272\u6c28\u9178\u3001\u7159\u9170\u80fa (Nam)\u3001\u83f8\u9178\uff08NA \u6216 niacin\uff09\u3001\u7159\u9170\u80fa\u6838\u82f7 (NR) \u548c\u7159\u9170\u80fa\u55ae\u6838\u82f7\u9178 (NMN)\u3002\u5176\u4e2d\uff0cNMN \u4ee3\u8868 NAD+ \u5408\u6210\u7684\u6700\u5f8c\u6b65\u9a5f\u4e4b\u4e00\u3002&nbsp;<\/p>\n\n\n\n<p>\u9019\u4e9b\u524d\u9ad4\u90fd\u53ef\u4ee5\u4f86\u81ea\u98f2\u98df\u3002 Nam\u3001NA \u548c NR \u90fd\u662f\u7dad\u751f\u7d20 B3 \u7684\u5f62\u5f0f\uff0c\u662f\u4e00\u7a2e\u91cd\u8981\u7684\u71df\u990a\u7d20\u3002\u4e00\u65e6\u9032\u5165\u9ad4\u5167\uff0c\u6211\u5011\u7684\u7d30\u80de\u5c31\u53ef\u4ee5\u901a\u904e\u5e7e\u7a2e\u4e0d\u540c\u7684\u9014\u5f91\u5408\u6210 NAD+\u3002\u4e00\u689d\u751f\u5316\u901a\u8def\u76f8\u7576\u65bc\u4e00\u689d\u5de5\u5ee0\u751f\u7522\u7dda\u3002\u5728 NAD+ \u7684\u60c5\u6cc1\u4e0b\uff0c\u591a\u689d\u751f\u7522\u7dda\u90fd\u5c0e\u81f4\u76f8\u540c\u7684\u7522\u54c1\u3002<\/p>\n\n\n\n<p>\u9019\u4e9b\u9014\u5f91\u4e2d\u7684\u7b2c\u4e00\u500b\u7a31\u70ba\u5f9e\u982d\u9014\u5f91\u3002 De novo \u662f\u4e00\u500b\u62c9\u4e01\u8a9e\u8868\u9054\uff0c\u76f8\u7576\u65bc\u201c\u5f9e\u982d\u958b\u59cb\u201d\u3002\u5f9e\u982d\u9014\u5f91\u5f9e\u6700\u65e9\u7684 NAD+ \u524d\u9ad4\u8272\u6c28\u9178\u958b\u59cb\uff0c\u4e26\u5f9e\u90a3\u88e1\u5411\u4e0a\u69cb\u5efa\u3002&nbsp;<\/p>\n\n\n\n<p>\u7b2c\u4e8c\u7a2e\u9014\u5f91\u7a31\u70ba\u88dc\u6551\u9014\u5f91\u3002\u88dc\u6551\u9014\u5f91\u985e\u4f3c\u65bc\u56de\u6536\u5229\u7528\uff0c\u56e0\u70ba\u5b83\u5f9e NAD+ \u964d\u89e3\u7684\u7522\u7269\u4e2d\u7522\u751f NAD+\u3002\u8eab\u9ad4\u5167\u7684\u6240\u6709\u86cb\u767d\u8cea\u90fd\u9700\u8981\u5b9a\u671f\u964d\u89e3\uff0c\u4ee5\u9632\u6b62\u5b83\u5011\u7a4d\u7d2f\u5230\u4e0d\u5065\u5eb7\u7684\u7a0b\u5ea6\u3002\u4f5c\u70ba\u9019\u500b\u751f\u7522\u548c\u964d\u89e3\u5faa\u74b0\u7684\u4e00\u90e8\u5206\uff0c\u9176\u63d0\u53d6\u86cb\u767d\u8cea\u964d\u89e3\u7684\u4e00\u4e9b\u7d50\u679c\uff0c\u4e26\u5c07\u5176\u653e\u56de\u540c\u4e00\u86cb\u767d\u8cea\u7684\u751f\u7522\u7dda\u3002&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4f86\u81ea NMN \u7684 NAD+ \u751f\u7269\u5408\u6210<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/static.wixstatic.com\/media\/55242c_a2117c24c43f428aa0fb06a72759f932~mv2.jpg\/v1\/fill\/w_837,h_494,al_c,q_85,usm_0.66_1.00_0.01,enc_auto\/nmn-5.jpg\" alt=\"nmn-5.jpg\"\/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>NMN\u662f\u5982\u4f55\u5728\u9ad4\u5167\u5408\u6210\u7684\uff1f<\/strong><\/h2>\n\n\n\n<p>NMN \u662f\u7531\u9ad4\u5167\u7684 B \u65cf\u7dad\u751f\u7d20\u7522\u751f\u7684\u3002\u8ca0\u8cac\u5728\u9ad4\u5167\u88fd\u9020 NMN \u7684\u9176\u7a31\u70ba\u7159\u9170\u80fa\u78f7\u9178\u6838\u7cd6\u8f49\u79fb\u9176 (NAMPT)\u3002 NAMPT \u5c07\u7159\u9170\u80fa\uff08\u4e00\u7a2e\u7dad\u751f\u7d20 B3\uff09\u9023\u63a5\u5230\u7a31\u70ba PRPP\uff085'-\u78f7\u9178\u6838\u7cd6\u57fa-1-\u7126\u78f7\u9178\uff09\u7684\u78f7\u9178\u7cd6\u4e0a\u3002 NMN \u4e5f\u53ef\u4ee5\u901a\u904e\u6dfb\u52a0\u78f7\u9178\u57fa\u5718\u7531\u201c\u7159\u9170\u80fa\u6838\u82f7\u201d\uff08NR\uff09\u88fd\u6210\u3002&nbsp;<\/p>\n\n\n\n<p>\u201cNAMPT\u201d\u662f NAD+ \u7522\u751f\u7684\u9650\u901f\u9176\u3002\u9019\u610f\u5473\u8457\u8f03\u4f4e\u6c34\u5e73\u7684 NAMPT \u6703\u5c0e\u81f4 NMN \u7522\u751f\u6e1b\u5c11\uff0c\u5f9e\u800c\u5c0e\u81f4 NAD+ \u6c34\u5e73\u964d\u4f4e\u3002\u6dfb\u52a0 NMN \u7b49\u524d\u9ad4\u5206\u5b50\u4e5f\u53ef\u4ee5\u52a0\u5feb NAD+ \u7684\u7522\u751f\u3002&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u63d0\u9ad8 NAD+ \u6c34\u5e73\u7684\u65b9\u6cd5<\/strong><\/h2>\n\n\n\n<p>\u7981\u98df\u6216\u6e1b\u5c11\u5361\u8def\u91cc\u651d\u5165\u91cf\uff0c\u5373\u5361\u8def\u91cc\u9650\u5236\uff0c\u5df2\u88ab\u8b49\u660e\u53ef\u4ee5\u589e\u52a0 NAD+ \u6c34\u5e73\u548c Sirtuin \u6d3b\u6027\u3002\u5728\u5c0f\u9f20\u4e2d\uff0c\u5361\u8def\u91cc\u9650\u5236\u5f15\u8d77\u7684 NAD+ \u548c\u6c88\u9ed8\u8abf\u7bc0\u86cb\u767d\u6d3b\u6027\u589e\u52a0\u5df2\u88ab\u8b49\u660e\u53ef\u4ee5\u6e1b\u7de9\u8870\u8001\u904e\u7a0b\u3002\u5118\u7ba1 NAD+ \u5b58\u5728\u65bc\u67d0\u4e9b\u98df\u7269\u4e2d\uff0c\u4f46\u5176\u6fc3\u5ea6\u592a\u4f4e\u800c\u7121\u6cd5\u5f71\u97ff\u7d30\u80de\u5167\u6fc3\u5ea6\u3002\u670d\u7528\u67d0\u4e9b\u88dc\u5145\u5291\uff0c\u5982 NMN\uff0c\u5df2\u88ab\u8b49\u660e\u6703\u589e\u52a0 NAD+ \u6c34\u5e73\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>NAD \u88dc\u5145\u4f5c\u70ba NMN<\/strong><\/h2>\n\n\n\n<p>\u96a8\u8457\u6b63\u5e38\u7d30\u80de\u529f\u80fd\u96a8\u8457\u6642\u9593\u7684\u63a8\u79fb\u6d88\u8017 NAD+ \u4f9b\u61c9\uff0c\u7d30\u80de\u5167 NAD+ \u7684\u6fc3\u5ea6\u6703\u96a8\u8457\u8870\u8001\u800c\u964d\u4f4e\u3002 NAD+ \u7684\u5065\u5eb7\u6c34\u5e73\u88ab\u8a8d\u70ba\u53ef\u4ee5\u901a\u904e\u88dc\u5145 NAD+ \u524d\u9ad4\u4f86\u6062\u5fa9\u3002\u6839\u64da\u7814\u7a76\uff0cNMN \u548c\u7159\u9170\u80fa\u6838\u82f7 (NR) \u7b49\u524d\u9ad4\u88ab\u8996\u70ba&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27374990\" target=\"_blank\" rel=\"noreferrer noopener\">NAD+ \u751f\u7522\u7684\u88dc\u5145\u5291\uff0c \u53ef\u589e\u52a0 NAD+ \u7684\u6fc3\u5ea6\u3002<\/a>\u54c8\u4f5b\u5927\u5b78 NAD+ \u7814\u7a76\u54e1 David Sinclair \u8aaa\uff1a\u201c\u76f4\u63a5\u7d66\u751f\u7269\u9ad4\u9935\u98df\u6216\u7ba1\u7406 NAD+ \u4e0d\u662f\u4e00\u500b\u5be6\u969b\u7684\u9078\u64c7\u3002 NAD+ \u5206\u5b50\u4e0d\u80fd\u8f15\u6613\u7a7f\u904e\u7d30\u80de\u819c\u9032\u5165\u7d30\u80de\uff0c\u56e0\u6b64\u7121\u6cd5\u5c0d\u65b0\u9673\u4ee3\u8b1d\u7522\u751f\u7a4d\u6975\u5f71\u97ff\u3002\u76f8\u53cd\uff0c\u5fc5\u9808\u4f7f\u7528 NAD+ \u7684\u524d\u9ad4\u5206\u5b50\u4f86\u63d0\u9ad8 NAD+ \u7684\u751f\u7269\u53ef\u5229\u7528\u6c34\u5e73\u3002\u201d\u9019\u610f\u5473\u8457 NAD+ \u4e0d\u80fd\u7528\u4f5c\u76f4\u63a5\u88dc\u5145\u5291\uff0c\u56e0\u70ba\u5b83\u4e0d\u5bb9\u6613\u88ab\u5438\u6536\u3002 NAD+ \u524d\u9ad4\u6bd4 NAD+ \u66f4\u5bb9\u6613\u5438\u6536\uff0c\u662f\u66f4\u6709\u6548\u7684\u88dc\u5145\u5291\u3002&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>NMN \u88dc\u5145\u5291\u5982\u4f55\u5728\u5168\u8eab\u5438\u6536\u548c\u5206\u4f48\uff1f<\/strong><\/h2>\n\n\n\n<p>&nbsp;NMN \u4f3c\u4e4e&nbsp;<a href=\"https:\/\/www.nature.com\/articles\/s42255-018-0015-\" target=\"_blank\" rel=\"noreferrer noopener\">\u901a\u904e\u5d4c\u5165\u7d30\u80de\u8868\u9762\u7684\u5206\u5b50\u8f49\u904b\u86cb\u767d\u88ab\u5438\u6536\u5230\u7d30\u80de\u4e2d\u3002<\/a>&nbsp;\u7531\u65bc\u6bd4 NAD+ \u5c0f\uff0cNMN \u5206\u5b50\u53ef\u4ee5\u66f4\u6709\u6548\u5730\u88ab\u7d30\u80de\u5438\u6536\u3002\u7531\u65bc\u7d30\u80de\u819c\u7684\u5c4f\u969c\u4f5c\u7528\uff0cNAD+ \u4e0d\u80fd\u8f15\u6613\u9032\u5165\u9ad4\u5167\u3002\u8a72\u819c\u5177\u6709\u7121\u6c34\u7a7a\u9593\uff0c\u53ef\u9632\u6b62\u96e2\u5b50\u3001\u6975\u6027\u5206\u5b50\u548c\u5927\u5206\u5b50\u5728\u4e0d\u4f7f\u7528\u8f49\u904b\u86cb\u767d\u7684\u60c5\u6cc1\u4e0b\u9032\u5165\u3002\u66fe\u7d93\u8a8d\u70ba NMN \u5fc5\u9808\u5728\u9032\u5165\u7d30\u80de\u4e4b\u524d\u88ab\u6539\u8b8a\uff0c\u4f46\u65b0\u7684\u8b49\u64da\u8868\u660e\u5b83\u53ef\u4ee5\u901a\u904e\u7d30\u80de\u819c\u4e2d\u7684 NMN \u7279\u7570\u6027\u8f49\u904b\u86cb\u767d\u76f4\u63a5\u9032\u5165\u7d30\u80de\u3002<\/p>\n\n\n\n<p>\u6b64\u5916\uff0c\u6ce8\u5c04 NMN \u6703\u5c0e\u81f4\u8eab\u9ad4\u8a31\u591a\u5340\u57df\u7684 NAD+ \u589e\u52a0\uff0c\u5305\u62ec\u80f0\u817a\u3001\u8102\u80aa\u7d44\u7e54\u3001\u5fc3\u81df\u3001\u9aa8\u9abc\u808c\u3001\u814e\u81df\u3001\u777e\u4e38\u3001\u773c\u775b\u548c\u8840\u7ba1\u3002\u5728\u5c0f\u9f20\u4e2d\u53e3\u670d NMN \u6703\u5728&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21982712\" target=\"_blank\" rel=\"noreferrer noopener\">15 \u5206\u9418\u5167\u589e\u52a0\u809d\u81df\u4e2d\u7684 NAD+ \u3002.<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>NMN \u5feb\u901f\u8f49\u63db\u70ba NAD+<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/static.wixstatic.com\/media\/55242c_8fea1e8355bd4c20b854e667f49d428b~mv2.jpg\/v1\/fill\/w_836,h_544,al_c,q_85,usm_0.66_1.00_0.01,enc_auto\/nmn-6.jpg\" alt=\"nmn-6.jpg\"\/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>NMN \u526f\u4f5c\u7528\u548c\u5b89\u5168\u6027<\/strong><\/h2>\n\n\n\n<p>NMN \u5728\u52d5\u7269\u4e2d\u88ab\u8a8d\u70ba\u662f\u5b89\u5168\u7684\uff0c\u7d50\u679c\u5f88\u6709\u5e0c\u671b\uff0c\u4eba\u985e\u81e8\u5e8a\u8a66\u9a57\u5df2\u7d93\u958b\u59cb\u3002\u9019\u7a2e\u5206\u5b50\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u88ab\u8a8d\u70ba\u662f\u5b89\u5168\u4e14\u7121\u6bd2\u7684\uff0c\u5373\u4f7f\u5728\u5c0f\u9f20\u548c\u4eba\u9ad4\u7814\u7a76\u4e2d\u6fc3\u5ea6\u5f88\u9ad8\u3002\u5c0f\u9f20\u9577\u671f\uff08\u4e00\u5e74\uff09\u53e3\u670d\u7d66\u85e5\u6c92\u6709\u6bd2\u6027\u4f5c\u7528\u3002\u7b2c\u4e00\u6b21\u4eba\u9ad4\u81e8\u5e8a\u8a66\u9a57\u5df2\u7d93\u5b8c\u6210\uff0c\u8b49\u64da\u652f\u6301\u55ae\u5291\u91cf\u7121\u6bd2\u7684\u89c0\u9ede\u3002&nbsp;<\/p>\n\n\n\n<p>\u5118\u7ba1 2019 \u5e74 11 \u6708\u767c\u8868\u7684\u4e00\u9805\u91dd\u5c0d\u65e5\u672c\u7537\u6027\u7684\u7814\u7a76\u6307\u51fa\uff0c\u670d\u7528 NMN \u5f8c\u53d7\u8a66\u8005\u8840\u6db2\u4e2d\u7684\u81bd\u7d05\u7d20\u6c34\u5e73\u5347\u9ad8\uff0c\u4f46\u9019\u4e9b\u6c34\u5e73\u4ecd\u8655\u65bc\u6b63\u5e38\u7bc4\u570d\u5167\u3002\u672a\u4f86\u7684\u7814\u7a76\u61c9\u5074\u91cd\u65bc\u4f7f\u7528\u7684\u9577\u671f\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002 NMN \u8207\u4efb\u4f55\u5176\u4ed6\u5df2\u77e5\u7684\u526f\u4f5c\u7528\u7121\u95dc\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>NMN \u548c NAD+ \u7684\u6b77\u53f2<\/strong><\/h2>\n\n\n\n<p>\u7159\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff0c\u7c21\u7a31 NAD\uff0c\u662f\u9ad4\u5167\u6700\u91cd\u8981\u3001\u7528\u9014\u6700\u5ee3\u7684\u5206\u5b50\u4e4b\u4e00\u3002\u56e0\u70ba\u5b83\u662f\u70ba\u7d30\u80de\u63d0\u4f9b\u80fd\u91cf\u7684\u6838\u5fc3\uff0c\u6240\u4ee5\u5e7e\u4e4e\u6c92\u6709\u4e0d\u9700\u8981 NAD \u7684\u751f\u7269\u904e\u7a0b\u3002\u56e0\u6b64\uff0cNAD \u6210\u70ba\u5ee3\u6cdb\u751f\u7269\u5b78\u7814\u7a76\u7684\u7126\u9ede\u3002<\/p>\n\n\n\n<p>1906 \u5e74\uff0c\u4e9e\u745f\u00b7\u54c8\u767b\u548c\u5a01\u5ec9\u00b7\u7d04\u7ff0\u00b7\u694a\u5728\u5f9e\u5564\u9152\u9175\u6bcd\u4e2d\u63d0\u53d6\u7684\u6db2\u9ad4\u4e2d\u767c\u73fe\u4e86\u4e00\u7a2e\u201c\u56e0\u5b50\u201d\uff0c\u53ef\u4ee5\u4fc3\u9032\u7cd6\u767c\u9175\u6210\u9152\u7cbe\u3002\u9019\u500b\u201c\u56e0\u7d20\u201d\uff0c\u7576\u6642\u88ab\u7a31\u70ba\u201ccoferment\u201d\uff0c\u7d50\u679c\u8b49\u660e\u662f NAD\u3002&nbsp;<\/p>\n\n\n\n<p>Harden \u548c Hans von Euler-Chelpin \u7e7c\u7e8c\u63ed\u958b\u767c\u9175\u7684\u5967\u79d8\u3002 1929 \u5e74\uff0c\u4ed6\u5011\u56e0\u6df1\u5165\u4e86\u89e3\u9019\u4e9b\u904e\u7a0b\uff0c\u5305\u62ec\u5f88\u5feb\u88ab\u7a31\u70ba NAD \u7684\u5316\u5b78\u5f62\u72c0\u548c\u7279\u6027\u800c\u7372\u5f97\u8afe\u8c9d\u723e\u734e\u3002 &nbsp;<\/p>\n\n\n\n<p>NAD \u7684\u6545\u4e8b\u5728 1930 \u5e74\u4ee3\u5f97\u5230\u64f4\u5c55\uff0c\u5728\u53e6\u4e00\u4f4d\u8afe\u8c9d\u723e\u734e\u7372\u5f97\u8005 Otto Warburg \u7684\u6307\u5c0e\u4e0b\uff0c\u4ed6\u767c\u73fe\u4e86 NAD \u5728\u4fc3\u9032\u8a31\u591a\u751f\u5316\u53cd\u61c9\u4e2d\u7684\u6838\u5fc3\u4f5c\u7528\u3002 Warburg \u767c\u73fe NAD \u4f5c\u70ba\u96fb\u5b50\u7684\u4e00\u7a2e\u751f\u7269\u4e2d\u7e7c\u3002&nbsp;<\/p>\n\n\n\n<p>\u96fb\u5b50\u5f9e\u4e00\u500b\u5206\u5b50\u8f49\u79fb\u5230\u53e6\u4e00\u500b\u5206\u5b50\uff0c\u4f5c\u70ba\u9032\u884c\u6240\u6709\u751f\u5316\u53cd\u61c9\u6240\u9700\u80fd\u91cf\u7684\u57fa\u790e\u3002&nbsp;<\/p>\n\n\n\n<p>1937 \u5e74\uff0c\u5a01\u65af\u5eb7\u661f\u5927\u5b78\u9ea5\u8fea\u905c\u5206\u6821\u7684 Conrad Elvehjem \u53ca\u5176\u540c\u4e8b\u767c\u73fe NAD+ \u88dc\u5145\u5291\u53ef\u4ee5\u6cbb\u6108\u72d7\u7684\u7cd9\u76ae\u75c5\u6216\u201c\u9ed1\u820c\u75c5\u201d\u3002\u5728\u4eba\u985e\u4e2d\uff0c\u7cd9\u76ae\u75c5\u6703\u5f15\u8d77\u4e00\u7cfb\u5217\u75c7\u72c0\uff0c\u5305\u62ec\u8179\u7009\u3001\u7661\u5446\u548c\u53e3\u8154\u6f70\u760d\u3002\u5b83\u6e90\u65bc\u83f8\u9178\u7f3a\u4e4f\u75c7\uff0c\u73fe\u5728\u5b9a\u671f\u7528\u7159\u9170\u80fa\u6cbb\u7642\uff0c\u7159\u9170\u80fa\u662f NMN \u7684\u524d\u9ad4\u4e4b\u4e00\u3002&nbsp;<\/p>\n\n\n\n<p>Arthur Kornberg \u5728 40 \u5e74\u4ee3\u548c 50 \u5e74\u4ee3\u5c0d NAD+ \u7684\u7814\u7a76\u6709\u52a9\u65bc\u4ed6\u767c\u73fe DNA \u8907\u88fd\u548c RNA \u8f49\u9304\u80cc\u5f8c\u7684\u539f\u7406\uff0c\u9019\u5169\u500b\u904e\u7a0b\u5c0d\u751f\u547d\u81f3\u95dc\u91cd\u8981\u3002&nbsp;<\/p>\n\n\n\n<p>1958 \u5e74\uff0cJack Preiss \u548c Philip Handler \u767c\u73fe\u4e86\u83f8\u9178\u8f49\u5316\u70ba NAD\u7684\u4e09\u500b\u751f\u5316\u6b65\u9a5f\u3002\u9019\u4e00\u7cfb\u5217\u6b65\u9a5f\u7a31\u70ba\u9014\u5f91\uff0c\u4eca\u5929\u7a31\u70ba Preiss-Handler \u9014\u5f91\u3002<\/p>\n\n\n\n<p>1963 \u5e74\uff0cChambon\u3001Weill \u548c Mandel \u5831\u544a\u8aaa\uff0c\u7159\u9170\u80fa\u55ae\u6838\u82f7\u9178(NMN) \u63d0\u4f9b\u4e86\u6fc0\u6d3b\u4e00\u7a2e\u91cd\u8981\u7684\u6838\u9176\u6240\u9700\u7684\u80fd\u91cf\u3002\u9019\u4e00\u767c\u73fe\u70ba\u95dc\u65bc\u4e00\u7a2e\u7a31\u70ba PARP \u7684\u86cb\u767d\u8cea\u7684\u4e00\u7cfb\u5217\u975e\u51e1\u767c\u73fe\u92ea\u5e73\u4e86\u9053\u8def\u3002 PARPs \u5728\u4fee\u5fa9 DNA \u640d\u50b7\u3001\u8abf\u7bc0\u7d30\u80de\u6b7b\u4ea1\u65b9\u9762\u8d77\u8457\u81f3\u95dc\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u5176\u6d3b\u6027\u8207\u58fd\u547d\u7684\u8b8a\u5316\u6709\u95dc\u3002<\/p>\n\n\n\n<p>1976 \u5e74\uff0cRechsteiner \u548c\u4ed6\u7684\u540c\u4e8b\u5011\u767c\u73fe\u4e86\u4ee4\u4eba\u4fe1\u670d\u7684\u8b49\u64da\uff0c\u9664\u4e86\u4f5c\u70ba\u80fd\u91cf\u8f49\u79fb\u5206\u5b50\u7684\u7d93\u5178\u751f\u5316\u4f5c\u7528\u4e4b\u5916\uff0cNAD+ \u4f3c\u4e4e\u53ef\u80fd\u5728\u54fa\u4e73\u52d5\u7269\u7d30\u80de\u4e2d\u5177\u6709\u201c\u5176\u4ed6\u4e00\u4e9b\u4e3b\u8981\u529f\u80fd\u201d\u3002&nbsp;<\/p>\n\n\n\n<p>\u9019\u4e00\u767c\u73fe\u4f7f Leonard Guarente \u548c\u4ed6\u7684\u540c\u4e8b\u5011\u6709\u53ef\u80fd\u767c\u73fe\u7a31\u70ba Sirtuins \u7684\u86cb\u767d\u8cea\u901a\u904e\u5dee\u7570\u6027\u5730\u4fdd\u6301\u67d0\u4e9b\u57fa\u56e0\u201c\u6c89\u9ed8\u201d\u4f86\u4f7f\u7528 NAD \u4f86\u5ef6\u9577\u58fd\u547d\u3002&nbsp;<\/p>\n\n\n\n<p>\u5f9e\u90a3\u6642\u8d77\uff0c\u4eba\u5011\u5c0d NAD \u53ca\u5176\u4e2d\u9593\u9ad4 NMN \u548c NR \u7684\u8208\u8da3\u65e5\u76ca\u6fc3\u539a\uff0c\u56e0\u70ba\u5b83\u5011\u5177\u6709\u6539\u5584\u8a31\u591a\u8207\u5e74\u9f61\u76f8\u95dc\u7684\u5065\u5eb7\u554f\u984c\u7684\u6f5b\u529b\u3002&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>NMN\u7684\u672a\u4f86<\/strong><\/h2>\n\n\n\n<p>\u6191\u85c9 NMN \u5728\u52d5\u7269\u7814\u7a76\u4e2d\u986f\u793a\u51fa\u7684\u6709\u5e0c\u671b\u7684\u6cbb\u7642\u7279\u6027\uff0c\u7814\u7a76\u4eba\u54e1\u7684\u76ee\u6a19\u662f\u4e86\u89e3\u9019\u7a2e\u5206\u5b50\u5982\u4f55\u5728\u4eba\u9ad4\u4e2d\u767c\u63ee\u4f5c\u7528\u3002\u6700\u8fd1\u5728\u65e5\u672c\u9032\u884c\u7684\u4e00\u9805\u81e8\u5e8a\u8a66\u9a57\u8868\u660e\uff0c\u8a72\u5206\u5b50\u5728\u6240\u7528\u5291\u91cf\u4e0b\u662f\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u7684\u3002\u66f4\u591a\u7684\u7814\u7a76\u548c\u4eba\u9ad4\u8a66\u9a57\u6b63\u5728\u9032\u884c\u4e2d\u3002\u5b83\u662f\u4e00\u7a2e\u5f15\u4eba\u5165\u52dd\u4e14\u7528\u9014\u5ee3\u6cdb\u7684\u5206\u5b50\uff0c\u6211\u5011\u9084\u6709\u5f88\u591a\u6771\u897f\u8981\u5f9e\u4e2d\u5b78\u7fd2\u3002<\/p>\n\n\n\n<p>Learn more about the <strong><a href=\"https:\/\/www.wellixx.com\/product\/\">product(NMN)<\/a><\/strong><\/p>\n\n\n\n<p>\u4e86\u89e3\u66f4\u591a\u95dc\u65bc\uff1a <strong><a href=\"https:\/\/marseille-quince.com\/what-is-pqq\/\">PQQ<\/a><\/strong><\/p>\n\n\n\n<p>\u4e86\u89e3\u66f4\u591a\u95dc\u65bc\uff1a <strong><a href=\"https:\/\/marseille-quince.com\/akgs-benefit\/\">AKG<\/a><\/strong><\/p>\n\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>What is NMN? What\u2019s NMN? NMN stands for&nbsp;nicotinamide mononucleotide, a molecule naturally occurring in all life forms. At the molecular level, it is a ribo-nucleotide, which is a basic structural unit of the nucleic acid RNA. Structurally, the molecule is composed of a nicotinamide group, a ribose and a phosphate group (Figure 1). NMN is &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/marseille-quince.com\/zh\/about-nmn\/\" class=\"more-link\">\u7e7c\u7e8c\u95b1\u8b80<span class=\"screen-reader-text\"> &#8220;About NMN&#8221;<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"footnotes":""},"class_list":["post-2032","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/pages\/2032","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/comments?post=2032"}],"version-history":[{"count":5,"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/pages\/2032\/revisions"}],"predecessor-version":[{"id":2426,"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/pages\/2032\/revisions\/2426"}],"wp:attachment":[{"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/media?parent=2032"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}