{"id":2814,"date":"2026-02-20T18:43:36","date_gmt":"2026-02-20T10:43:36","guid":{"rendered":"https:\/\/marseille-quince.com\/?page_id=2814"},"modified":"2026-02-23T12:32:13","modified_gmt":"2026-02-23T04:32:13","slug":"can-cells-be-immortal-there-are-tips-for-fighting-aging","status":"publish","type":"page","link":"https:\/\/marseille-quince.com\/zh\/can-cells-be-immortal-there-are-tips-for-fighting-aging\/","title":{"rendered":"\u7d30\u80de\u53ef\u4ee5\u6c38\u751f\u4e0d\u6ec5\u55ce\uff1f\u5c0d\u6297\u8870\u8001\u6709\u6487\u6b65"},"content":{"rendered":"
\"\"\/<\/figure>\n\n\n\n

\u5728\u4e0a\u4e00\u7bc7\u63d0\u5230\u8207\u8001\u5316\u6709\u95dc\u7684\u6210\u56e0\u53ca\u4f5c\u7528\u6a5f\u8f49\uff0c\u672c\u7bc7\u5c07\u7279\u5225\u8a0e\u8ad6\u4e00\u4e9b\u5c0d\u6297\u8870\u8001\u7684\u65b9\u6cd5\u53ca\u767c\u5c55\u8da8\u52e2\u3002\u5176\u5be6\uff0c\u5168\u4e16\u754c\u5404\u5730\u5230\u76ee\u524d\u70ba\u6b62\uff0c\u5df2\u6709\u90e8\u5206\u91ab\u5b78\u7642\u6cd5\u53ca\u5ef6\u58fd\u6280\u8853\u5b58\u5728\uff0c\u4f46\u6709\u4e9b\u4ecd\u9700\u7b49\u4e0a\u6578\u5e74\uff0c\u751a\u81f3\u9084\u8981\u82b1\u4e0a\u6578\u5341\u5e74\u624d\u80fd\u514b\u670d\u3002<\/p>\n\n\n\n

\u5728\u904e\u53bb\u5e7e\u5e74\u4f86\uff0c\u8af8\u5982\u65e5\u672c\u6c96\u7e69\uff08Okinawa\uff09\uff0c\u54e5\u65af\u5927\u9ece\u52a0\u5c3c\u79d1\u4e9e\u534a\u5cf6\uff08Nicoya\uff09\u548c\u7fa9\u5927\u5229\u85a9\u4e01\u5c3c\u4e9e\u534a\u5cf6\uff08Sardinia\uff09\u7b49\u6709\u5f88\u591a\u767e\u6b72\u4eba\u745e\uff0c\u4e00\u76f4\u90fd\u88ab\u63a2\u8a0e\u9577\u58fd\u7684\u539f\u56e0\uff0c\u662f\u6700\u88ab\u95dc\u6ce8\u7684\u91cd\u9ede\uff1a\u98f2\u98df\u3001\u751f\u6d3b\u65b9\u5f0f\u3001\u904b\u52d5\u7fd2\u6163\u53ca\u5c45\u5bb6\u74b0\u5883\uff0c\u90fd\u88ab\u5ee3\u6cdb\u8a0e\u8ad6\uff0c\u4ee5\u4e0b\u91dd\u5c0d\u6700\u8fd1\u7814\u7a76\u6587\u737b\u3001\u76f8\u95dc\u8abf\u67e5\u53ca\u6700\u8fd1\u6297\u8870\u8001\u65b0\u767c\u73fe\uff0c\u505a\u7d9c\u5408\u6574\u7406\u8207\u8b80\u8005\u5206\u4eab\u3002<\/p>\n\n\n\n

\u9577\u58fd\u98f2\u98df\u5b58\u5728\u55ce?<\/strong><\/p>\n\n\n\n

\u7f8e\u570b\u8457\u540d\u4f5c\u5bb6Dan Buettner\u66fe\u57282003\u5e74\u4ecb\u7d39\u300c\u85cd\u8272\u5bf6\u5730\u300d\uff08Blue Zones\uff09\u5730\u5340\uff0c\u63a2\u8a0e\u5c45\u6c11\u98f2\u98df\u8207\u9577\u58fd\u7684\u95dc\u4fc2\u3002\u5927\u90e8\u5206\u7684\u4eba\u591a\u5403\u852c\u679c\u3001\u8c46\u985e\u548c\u5168\u9ea5\u7a40\u7269\uff0c\u5c11\u5403\u7d05\u8089\u548c\u7cd6\u53ca\u52d5\u7269\u6027\u8102\u80aa\u3002\u4f46\u4ec0\u9ebc\u662f\u6700\u4f73\u9577\u58fd\u98f2\u98df\uff0c\u4e00\u76f4\u5b58\u5728\u5f88\u5927\u7684\u5206\u6b67\uff0c\u4eba\u5404\u6709\u5176\u98f2\u98df\u7fd2\u6163\u4e0d\u76e1\u76f8\u540c\uff0c\u5373\u4f7f\u4e16\u754c\u6700\u9802\u5c16\u7684\u71df\u990a\u5b78\u5bb6\uff0c\u4ea6\u5404\u6709\u4e3b\u5f35\uff0c\u83ab\u8877\u4e00\u662f\u3002<\/p>\n\n\n\n

\u95dc\u65bc\u9577\u58fd\u98f2\u98df\uff0c\u9060\u81ea\u53e4\u5e0c\u81d8\u8607\u683c\u62c9\u5e95\u6642\u4ee3\uff0c\u7576\u6642\u7684\u91ab\u5e2b\u5c31\u5efa\u8b70\u9650\u5236\u98f2\u98df\uff0c\u4f46\u7121\u5be6\u8b49\u91ab\u5b78\u7684\u652f\u6301\uff0c\u4e43\u81f31935\u5e74\u5eb7\u4e43\u723e\u5927\u5b78\u6559\u6388\u514b\u840a\u592b\u00b7\u9ea5\u51f1\uff08Clive McCay\uff09\u8b49\u660e\u5c0f\u9f20\u9650\u5236\u98f2\u98df\u71b1\u91cf20%\uff0c\u6bd4\u8d77\u6b63\u5e38\u98f2\u98df\u7684\u63a7\u5236\u7d44\uff0c\u58fd\u547d\u660e\u986f\u589e\u9577\uff0c\u4e26\u767c\u8868\u65bc\u300a\u79d1\u5b78\u671f\u520a\u300b\uff08Science\uff09\uff08\u5716\u4e00\uff09\uff0c\u63a5\u4e0b\u4f86\u9577\u905480\u5e74\u7684\u7814\u7a76\u4e00\u518d\u8b49\u5be6\uff0c\u5728\u7121\u71df\u990a\u4e0d\u826f\u60c5\u6cc1\u4e0b\u7684\u71b1\u91cf\u9650\u5236\u6cd5\uff08Calorie restriction,CR\uff09\u6709\u76ca\u65bc\u5ef6\u9577\u58fd\u547d\uff0c\u5305\u62ec\u9175\u6bcd\u83cc\u3001\u679c\u8805\u53ca\u9f67\u9f52\u985e\u52d5\u7269\u5747\u6709\u540c\u6a23\u5831\u544a\u3002<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

1978\u5e74\u65e5\u672c\u9999\u5ddd\u9756\u96c4\uff08Yasuo Kagawa\uff09\u5728\u6c96\u7e69\u5cf6\u9032\u884c\u7814\u7a76\uff0c\u4ea6\u6709\u540c\u6a23\u7684\u5831\u544a\uff0c\u800c\u5f8c\u76f8\u7e7c\u6709\u5f88\u591a\u7684\u985e\u4f3c\u7814\u7a76\u6210\u679c\uff0c\u9664\u4e86\u71b1\u91cf\u9650\u5236\u4ee5\u5916\uff0c\u98f2\u98df\u65b9\u5f0f\u4ea6\u5f88\u91cd\u8981\uff0c\u76ee\u524d\u4e00\u4e9b\u98f2\u98df\u9650\u5236\u65b9\u5f0f\uff0c\u5305\u62ec\u4e0d\u5403\u65e9\u9910\u3001\u665a\u9ede\u5403\u5348\u9910\u768416\uff1a8\u98f2\u98df\u6cd5\uff0c\u53ca\u6bcf\u9031\u9078\u64c7\u5169\u5929\u5403\u5c11\u65bc75%\u71b1\u91cf\uff085\uff1a2\u8f15\u65b7\u98df\uff09\u3002 breakfast<\/a>, eating lunch late, and choosing to eat less than two days a week 75% calories (5:2 light fasting).<\/p>\n\n\n\n

\u4f46\u73fe\u4ee3\u4eba\u7684\u98f2\u98df\u7fd2\u6163\u6f14\u8b8a\u81f3\u4eca\uff0c\u5c0d\u8a31\u591a\u4eba\u4f86\u8aaa\uff0c\u4efb\u4f55\u5f62\u5f0f\u7684\u7981\u98df\u6050\u6015\u7121\u6cd5\u9577\u671f\u5805\u6301\u4e0b\u53bb\uff0c\u6240\u4ee5\uff0c\u73fe\u5728\u6bd4\u8f03\u5bb9\u6613\u4e14\u5ee3\u88ab\u63a5\u53d7\u7684\u98f2\u98df\u6700\u9ad8\u6307\u5c0e\u539f\u5247\uff0c\u5c31\u662f\u53bb\u9664\u9020\u6210\u7d30\u80de\u8870\u8001\u53ca\u7d30\u80de\u7aef\u7c92\u8b8a\u77ed\u7684\u4e09\u5bb3\uff08\u767c\u708e\u3001\u6c27\u5316\u58d3\u529b\u53ca\u80f0\u5cf6\u7d20\u963b\u6297\uff09\uff0c\u5982\u679c\u63a1\u7528\u7684\u98f2\u98df\u80fd\u5c07\u6297\u767c\u708e\u3001\u6297\u6c27\u5316\u58d3\u529b\u3001\u6297\u80f0\u5cf6\u7d20\u963b\u6297\uff0c\u90a3\u5c31\u662f\u63a5\u8fd1\u65bc\u9577\u58fd\u7684\u6700\u4f73\u98f2\u98df\uff0c\u4e5f\u5c31\u662f\u591a\u5403\u542b\u6709Omega-3\u8102\u80aa\u9178\uff08EPA\u53caDHA\uff09\u7684\u98df\u7269\uff08\u50cf\u6d77\u85fb\u53ca\u9b5a\uff09\uff0c\u591a\u5403\u542b\u6709\u7e96\u7dad\u7d20\u3001\u6297\u6c27\u5316\u7269\u548c\u985e\u9ec3\u916e\uff08\u50cf\u852c\u83dc\u3001\u6c34\u679c\uff09\uff0c\u76e1\u91cf\u5c11\u5403\u7d05\u8089\u53ca\u7cbe\u7dfb\u7cd6\u7b49\uff0c\u4e00\u822c\u6240\u8b02\u7684\u5730\u4e2d\u6d77\u98f2\u98df\u5c31\u662f\u503c\u5f97\u63a8\u85a6\u7684\u98f2\u98df\u65b9\u5f0f\uff08\u5716\u4e8c\uff09\uff0c\u800c\u4e14\u53ef\u4f7f\u7aef\u7c92\u4e0d\u81f4\u8b8a\u77ed\u3002<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

\u53e6\u5916\uff0c\u7f8e\u570b\u7814\u7a76\u8001\u5316\u7684\u5927\u5e2bDr.Sinclair\u4e5f\u540c\u610f\u9650\u5236\u71b1\u91cf\u662f\u589e\u9032\u9577\u58fd\u7684\u597d\u65b9\u6cd5\uff0c\u7531\u65bc\u4f0a\u8389\u838e\u767d\uff0e\u5e03\u96f7\u514b\u672c\u7b49\u4e09\u4eba\u767c\u73fe\u7aef\u7c92\u8207\u58fd\u547d\u6709\u95dc\uff0c\u800c\u4e14\u9577\u58fd\u7684\u4eba\u5176\u7aef\u7c92\u9577\u5ea6\u90fd\u6bd4\u77ed\u547d\u7684\u4eba\u8f03\u9577\uff0c\u7d30\u80de\u4e5f\u4e0d\u6613\u8870\u8001\uff0c\u6b64\u9805\u91cd\u5927\u767c\u73fe\uff0c\u975e\u5e38\u91cd\u8981\uff0c\u56e0\u800c\u57282009\u5e74\u7372\u5f97\u8afe\u8c9d\u723e\u91ab\u5b78\u734e\uff08\u5716\u4e09\uff09\uff0c\u800c\u5f8c\u5f88\u591a\u4eba\u722d\u76f8\u63a2\u8a0e\u54ea\u4e9b\u98df\u7269\u8207\u71df\u990a\u7d20\u53ef\u4ee5\u589e\u52a0\u7aef\u7c92\u7684\u9577\u5ea6\uff0c\u5230\u76ee\u524d\u6839\u64da\u8af8\u591a\u5b78\u8853\u7814\u7a76\uff0c\u6709\u6bd4\u8f03\u4e00\u81f4\u7684\u770b\u6cd5\uff0c\u5982\u4e0b\u5217\uff08\u8868\u4e00\uff09\u53ca\uff08\u8868\u4e8c\uff09\u6240\u793a\uff0c\u4f9b\u8b80\u8005\u53c3\u8003\u3002<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n
\"\"<\/a><\/figure>\n\n\n\n
\"\"<\/a><\/figure>\n\n\n\n

\u7576\u7136\u50cf\u8461\u8404\u53ca\u7d05\u9152\u4e2d\u7684\u767d\u85dc\u8606\u9187\uff08Resveratrol\uff09\u3001\u4e01\u9999\u4e2d\u7684\u4e8c\u7532\u96d9\u80cd\uff08Metformin\uff09\u3001\u7d05\u6d0b\u8525\u4e2d\u7684\u69f2\u76ae\u7d20\uff08Quercetin\uff09\u7b49\uff0c\u90fd\u662f\u9019\u4e9b\u690d\u7269\u5728\u751f\u9577\u904e\u7a0b\u4e2d\u9762\u81e8\u6c23\u5019\u6eab\u5dee\u8b8a\u5316\u6216\u5176\u4ed6\u58d3\u529b\u6240\u7522\u751f\u7684\u5316\u5b78\u7269\u8cea\uff0c\u5177\u6709\u7570\u8cea\u6fc0\u6548\u4f5c\u7528\uff08Xenohormesis\uff09\uff0c\u5c0d\u4eba\u9ad4\u5065\u5eb7\u9817\u6709\u52a9\u76ca\uff0c\u53ef\u6d3b\u5316\u53bb\u4e59\u91af\u9176\uff0c\u9032\u800c\u6fc0\u6d3b\u9577\u58fd\u57fa\u56e0\uff0c\u9019\u4e9b\u90fd\u662f\u76ee\u524d\u975e\u5e38\u71b1\u9580\u7814\u7a76\u7684\u6297\u8001\u98df\u7269\uff0c\u9019\u610f\u5473\u8457\u5728\u81ea\u7136\u754c\u5c0b\u627e\u65b0\u85e5\u6642\uff0c\u61c9\u8a72\u8981\u5f9e\u5728\u81ea\u7136\u754c\u5c0b\u8993\u627f\u53d7\u58d3\u529b\u5927\u7684\u690d\u7269\u7b49\u8457\u624b\uff0c\u6bd4\u8f03\u80fd\u5c0d\u6297\u6eab\u5dee\u3001\u4e7e\u65f1\u3001\u571f\u58e4\u71df\u990a\u4e0d\u826f\u7684\u690d\u7269\u3001\u771f\u8568\u751a\u6216\u5728\u4eba\u6216\u52d5\u7269\u9ad4\u5167\u7684\u83cc\u53e2\uff08microbiome\uff09\u3002<\/p>\n\n\n\n

\u898f\u5f8b\u904b\u52d5\u6709\u76ca\u9577\u58fd\u55ce\uff1f<\/strong><\/p>\n\n\n\n

\u6839\u64da\u7f8e\u570b\u75be\u75c5\u63a7\u5236\u8207\u9810\u9632\u4e2d\u5fc3\uff08Centers for Disease Control and Prevention\uff0cCDC\uff09\u57282017\u5e74\u7684\u4e00\u9805\u7814\u7a76\u6307\u51fa\uff0c\u6bcf\u9031\u81f3\u5c11\u4e94\u5929\u6162\u8dd1\u534a\u5c0f\u6642\u7684\u4eba\uff0c\u6bd4\u4e45\u5750\u4e0d\u52d5\u7684\u4eba\uff0c\u5176\u7aef\u7c92\u986f\u7136\u5e74\u8f15\u8fd110\u5e74\uff0c\u6839\u64da\u591a\u9805\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u904b\u52d5\u53ef\u63d0\u9ad8\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\uff08Nicotinamide adenine dinucleotide\uff0cNAD\uff09\u7684\u6fc3\u5ea6\uff0c\u53ef\u4ee5\u589e\u52a0\u80fd\u91cf\u7522\u751f\uff0c\u6709\u52a9\u65bc\u9577\u58fd\u8abf\u63a7\u56e0\u5b50AMPK\u3001mTOR\u548c\u53bb\u4e59\u91af\u9176\uff08deacetylase\uff09\u6b63\u5411\u8abf\u7bc0\uff0c\u53ef\u4ee5\u6539\u5584\u5fc3\u80ba\u529f\u80fd\u53ca\u5ef6\u9577\u7aef\u7c92\u9577\u5ea6\u3002<\/p>\n\n\n\n

\u8fd1\u671f\u7684\u7814\u7a76\u66f4\u767c\u73fe\uff0c\u53ea\u8981\u6bcf\u5929\u670915\u5206\u9418\u7684\u898f\u5f8b\u904b\u52d5\uff0c\u4e5f\u6709\u76ca\u65bc\u5ef6\u9577\u58fd\u547d\uff0c\u6e1b\u5c11\u5fc3\u81df\u75c5\u767c\u4f5c\uff0c\u964d\u4f4e\u6b7b\u4ea1\u7387\uff1b \u53e6\u5916<\/a> \u53e6\u5916\uff0c\u8b93\u5fc3\u8df3\u52a0\u5feb\u7684\u904b\u52d5\uff0c\u53ef\u4ee5\u6d3b\u5316\u5982SIR2\u7b49\u9577\u58fd\u57fa\u56e0\uff0c\u4ea6\u53ef\u5ef6\u9577\u7aef\u7c92\u9577\u5ea6\uff0c\u589e\u52a0\u7c92\u817a\u9ad4\u6d3b\u6027\uff0c\u5c0d\u58fd\u547d\u589e\u9577\u5f88\u6709\u52a9\u76ca\u3002<\/p>\n\n\n\n

\u58d3\u529b\u662f\u4e00\u9ad4\u5169\u9762\uff0c\u53ef\u597d\u53ef\u58de\uff1f<\/strong><\/p>\n\n\n\n

\u51e1\u4eba\u7684\u4e00\u751f\uff0c\u5fc5\u7136\u9762\u5c0d\u58d3\u529b\uff0c\u5230\u5e95\u662f\u597d\u662f\u58de\uff0c\u4e00\u76f4\u662f\u5c08\u5bb6\u5b78\u8005\u722d\u76f8\u8a0e\u8ad6\u7684\u71b1\u9580\u8b70\u984c\u3002\u4e00\u822c\u800c\u8a00\uff0c\u77ed\u671f\u58d3\u529b\u53cd\u800c\u53ef\u4ee5\u589e\u9032\u7d30\u80de\u7684\u5065\u5eb7\uff0c\u4e0d\u81f3\u65bc\u4f7f\u7aef\u7c92\u8b8a\u77ed\uff0c\u6b64\u7a2e\u73fe\u8c61\u53eb\u300c\u8208\u596e\u6548\u61c9\u300d\uff08Hormesis\uff09\uff0c\u7b49\u65bc\u9762\u5c0d\u53ef\u627f\u53d7\u7684\u58d3\u529b\u53cd\u800c\u662f\u4e00\u7a2e\u6b63\u5411\u6311\u6230\uff0c\u5373\u6240\u8b02\u300c\u6311\u6230\u53cd\u61c9\u300d\uff08Challenge response\uff09\uff0c\u96d6\u7136\u4f7f\u4f60\u5fc3\u8df3\u52a0\u5feb\uff0c\u4f46\u8840\u6db2\u542b\u6c27\u91cf\u589e\u52a0\uff0c\u9ad4\u5167\u91cd\u8981\u5668\u5b98\u7684\u8840\u6d41\u91cf\u589e\u52a0\uff08\u5982\u5fc3\u81df\u53ca\u8166\u90e8\uff09\uff0c\u53ef\u4ee5\u4f7f\u4eba\u8208\u596e\uff0c\u6e3e\u8eab\u662f\u52c1\u3002<\/p>\n\n\n\n

\u5982\u679c\u627f\u53d7\u58d3\u529b\u904e\u5927\u6216\u904e\u9577\uff0c\u5247\u8b8a\u6210\u5a01\u8105\u53cd\u61c9\uff08Threat response\uff09\uff0c\u6b64\u6642\u53cd\u800c\u9020\u6210\u7126\u616e\u3001\u6050\u61fc\uff0c\u5c0e\u81f4\u8840\u7ba1\u6536\u7e2e\uff0c\u6d41\u5411\u8166\u90e8\u8840\u6db2\u8b8a\u5c11\uff0c\u8ff7\u8d70\u795e\u7d93\u6d3b\u52d5\u8b8a\u5c11\uff0c\u814e\u4e0a\u817a\u5206\u6ccc\u76ae\u8cea\u9187\uff0c\u4f7f\u8840\u7cd6\u4e0a\u5347\uff0c\u53cd\u800c\u4e0d\u5229\u65bc\u7aef\u7c92\u7684\u5065\u5eb7\uff0c\u4f7f\u7d30\u80de\u8da8\u5411\u8870\u8001\u3002\u6240\u4ee5\u5728\u4eba\u7684\u4e00\u751f\u7576\u4e2d\uff0c\u5982\u4f55\u5316\u963b\u529b\u70ba\u52a9\u529b\uff0c\u4f7f\u6311\u6230\u53cd\u61c9\u53d6\u4ee3\u5a01\u8105\u53cd\u61c9\u8b8a\u6210\u512a\u52e2\uff0c\u4e0d\u8981\u4f7f\u7aef\u7c92\u7684\u5065\u5eb7\u53d7\u5230\u50b7\u5bb3\uff0c\u76f8\u5c0d\u514d\u75ab\u7d30\u80de\u6703\u5f37\u5316\uff0c\u4e0d\u597d\u7684\u767c\u708e\u53cd\u61c9\u6703\u6e1b\u5c11\u3002\u6839\u64daDr.Kross\u3001Dr.Ayduk\u53caDr.Elissa Epel\u7b49\u4eba\u7814\u7a76\u8b49\u5be6\uff0c\u5982\u679c\u8655\u65bc\u9ad8\u5ea6\u58d3\u529b\u60c5\u6cc1\u4e0b\uff0c\u80fd\u5920\u9694\u96e2\u601d\u8003\u8207\u60c5\u611f\uff0c\u5229\u7528\u6b63\u5ff5\u6e1b\u58d3\u3001\u51a5\u60f3\u3001\u745c\u4f3d\u3001\u592a\u6975\u62f3\u6216\u6c23\u529f\u7b49\u65b9\u5f0f\uff0c\u53ef\u4f7f\u58d3\u529b\u8b8a\u6210\u6b63\u5411\uff0c\u53cd\u800c\u6709\u76ca\u3002<\/p>\n\n\n\n

\u6b64\u5916\uff0c\u5728\u7f8e\u570b\u9000\u4f11\u8005\u5354\u6703\u63a8\u52d5\u4e00\u9805\u8a08\u756b\uff0c\u6210\u7acb\u5fd7\u5de5\u9ad4\u9a57\u71df\uff08Experience Corps\uff09\u865f\u53ec\u9000\u4f11\u8001\u4eba\u81f3\u5f31\u52e2\u5718\u9ad4\uff0c\u9032\u884c\u6258\u80b2\u7167\u9867\u6216\u8ab2\u5f8c\u8f14\u5c0e\u7684\u5fd7\u5de5\u670d\u52d9\uff0c\u767c\u73fe\u9000\u4f11\u8001\u4eba\u5728\u7167\u9867\u5f31\u52e2\u5152\u7ae5\u904e\u7a0b\u4e2d\u521d\u671f\u6709\u58d3\u529b\uff0c\u4f46\u5f8c\u4f86\u8b49\u5be6\u5c0d\u96d9\u65b9\u90fd\u6709\u5e6b\u52a9\u3002\u53f0\u7063\u76ee\u524d\u898f\u756b\u5be6\u884c\u7684\u300c\u9752\u9280\u5171\u5c45\u300d\u8a08\u756b\uff0c\u4ea6\u6709\u5b78\u7406\u4e0a\u7684\u6b63\u9762\u6548\u679c\uff0c\u900f\u904e\u9752\u9280\u5171\u5c45\uff0c\u8001\u5e74\u4eba\u53cd\u800c\u66f4\u5065\u5eb7\uff0c\u53ef\u4ee5\u5ef6\u9072\u8001\u5316\uff0c\u800c\u5e74\u8f15\u4eba\u4e0d\u6703\u56e0\u8207\u8001\u5e74\u4eba\u5728\u4e00\u8d77\u800c\u52a0\u901f\u8001\u5316\uff0c\u5177\u6709\u96d9\u8d0f\u7684\u6548\u679c\uff08\u5716\u56db\uff09\u3002<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

\u512a\u8cea\u7684\u7761\u7720\u53ef\u4ee5\u6e1b\u7de9\u8001\u5316<\/strong><\/p>\n\n\n\n

\u4eba\u7684\u4e00\u751f\uff0c\u67091\uff0f3\u6642\u9593\u5728\u7761\u89ba\uff0c\u7761\u7720\u54c1\u8cea\u4e0d\u597d\u3001\u7761\u7720\u4e0d\u8db3\u548c\u7761\u7720\u969c\u7919\uff0c\u90fd\u548c\u7aef\u7c92\u8b8a\u77ed\u6709\u95dc\uff0c\u7aef\u7c92\u4e5f\u9700\u8981\u7761\u7720\uff0c\u6211\u5011\u73fe\u5728\u5df2\u7d93\u77e5\u9053\uff0c\u5c0d\u6240\u6709\u6210\u5e74\u4eba\u4f86\u8aaa\uff0c\u5145\u8db3\u7684\u7761\u7720\u5c0d\u7aef\u7c92\u7684\u5065\u5eb7\u5f88\u91cd\u8981\uff0c\u6162\u6027\u5931\u7720\u6703\u4f7f\u7aef\u7c92\u8b8a\u77ed\uff0c\u7279\u5225\u662f70\u6b72\u4ee5\u4e0a\u7684\u4eba\u3002<\/p>\n\n\n\n

\u52a0\u5dde\u5927\u5b78\u67cf\u514b\u840a\u5206\u6821\u7684\u7761\u7720\u7814\u7a76\u4eba\u54e1\u6c83\u514b\uff08Matt Walker\uff09\u8aaa\u9053\uff1a\u300c\u7761\u7720\u8b93\u6211\u5011\u8a18\u61b6\u529b\u8b8a\u5f37\uff0c\u5982\u679c\u7761\u5f97\u597d\uff0c\u5c31\u80fd\u589e\u9032\u5b78\u7fd2\u80fd\u529b\u548c\u8a18\u61b6\u529b\u300d\u3002\u6839\u64da\u8457\u540d\u7684\u82f1\u570b\u767d\u5ef3\u7814\u7a76\uff08Whitehall study\uff09\uff0c\u6bcf\u665a\u7761\u7720\u6642\u9593\u5c11\u65bc5\u5c0f\u6642\u7537\u6027\uff0c\u8981\u6bd4\u7761\u7720\u6642\u9593\u8d85\u904e7\u5c0f\u6642\u8005\uff0c\u7aef\u7c92\u6bd4\u8f03\u77ed\u3002<\/p>\n\n\n\n

\u56e0\u6b64\uff0c\u8981\u7dad\u8b77\u7aef\u7c92\u5065\u5eb7\uff0c\u4f3c\u4e4e\u81f3\u5c11\u8981\u77617\u500b\u5c0f\u6642\uff0c\u53e6\u5916\uff0c\u4e0d\u53ea\u7761\u7720\u9577\u5ea6\uff0c\u7761\u7720\u54c1\u8cea\u548c\u7761\u7720\u7bc0\u5f8b\u4e5f\u5f88\u91cd\u8981\uff0c\u5e74\u8001\u6642\u5982\u679c\u7761\u7720\u54c1\u8cea\u826f\u597d\uff0c\u7aef\u7c92\u9577\u5ea6\u5c31\u80fd\u4fdd\u6301\u7a69\u5b9a\uff0c\u66f4\u91cd\u8981\u7684\u9664\u4e86\u7761\u7720\u9577\u5ea6\u548c\u7761\u7720\u54c1\u8cea\uff0c\u7761\u7720\u7bc0\u5f8b\u4e5f\u5f88\u91cd\u8981\uff0c\u4e5f\u5c31\u662f\u5b9a\u6642\u4e0a\u5e8a\u3001\u8d77\u5e8a\uff0c\u56e0\u70ba\u9019\u95dc\u4e4e\u7d30\u80de\u8abf\u7bc0\u7aef\u7c92\u9176\u7684\u80fd\u529b\uff0c\u6240\u4ee5\u5e74\u7d00\u6b65\u516560\u6b72\u4ee5\u4e0a\uff0c\u4e00\u5b9a\u8981\u6709\u826f\u597d\u7684\u7761\u7720\u7b56\u7565\u8207\u5be6\u969b\u4f5c\u70ba\uff0c\u8981\u78ba\u5be6\u638c\u63e1\u4e0b\u52176\u9ede\uff1a<\/p>\n\n\n\n

1. \u7d66\u81ea\u5df1\u4e00\u6bb5\u7761\u524d\u7684\u5e73\u975c\u6642\u9593\uff1a\u5982\u6d17\u500b\u6fa1\u3001\u770b\u8edf\u6027\u8b80\u7269\u3001\u807d\u8f15\u9b06\u97f3\u6a02\u6216\u975c\u5750\u51a5\u60f3\u7b49\u3002<\/p>\n\n\n\n

2. \u95dc\u6389\u85cd\u5149\u87a2\u5e55\u53ca\u5404\u7a2e3C\u7528\u54c1\uff0c\u963b\u7d55\u5404\u7a2e\u5149\u7dda\uff0c\u5e8a\u8207\u6795\u982d\u8981\u8edf\u786c\u9069\u4e2d\uff0c\u9069\u5408\u500b\u4eba\u9700\u6c42\u3002<\/p>\n\n\n\n

3. \u8a2d\u6cd5\u9694\u96e2\u566a\u97f3\u3002<\/p>\n\n\n\n

4. \u5b9a\u6642\u5403\u98ef\u3001\u898f\u5f8b\u4f5c\u606f\uff0c\u907f\u514d\u5403\u5bb5\u591c\u3002<\/p>\n\n\n\n

5. \u4e0d\u8981\u62d6\u5ef6\u4e0a\u5e8a\u7761\u89ba\u7684\u6642\u9593\uff08\u6700\u597d\u5728\u665a\u959310\u9ede\u5c31\u5be2\uff0c\u6700\u665a\u4e0d\u8d85\u904e11\u9ede\uff09\u3002<\/p>\n\n\n\n

6. \u61c9\u6cbb\u597d\u7761\u7720\u547c\u5438\u4e2d\u6b62\u75c7\u548c\u6253\u9f3e\u7b49\u6bdb\u75c5\u3002<\/p>\n\n\n\n

\u9006\u9f61\u6297\u8001\u6709\u4ed9\u4e39\u55ce\uff1f<\/strong><\/p>\n\n\n\n

\u79e6\u59cb\u7687\u5728\u897f\u5143\u524d219\u5e74\u70ba\u4e86\u9577\u58fd\uff0c\u6d3e\u5f90\u798f\u7387\u9818\u6578\u5343\u4eba\u5230\u6771\u701b\u5c0b\u627e\u9577\u751f\u4e0d\u8001\u85e5\uff0c\u4e8c\u6b21\u51fa\u6d77\u90fd\u7121\u6cd5\u9054\u6210\u4efb\u52d9\u3002\u4f46\u5982\u4f55\u5c0d\u6297\u8001\u5316\uff0c\u51cd\u9f61\u3001\u9006\u9f61\u3001\u5ef6\u5e74\u76ca\u58fd\uff0c\u4e00\u76f4\u662f\u5168\u4e16\u754c\u5c08\u5bb6\u5b78\u8005\u50be\u5168\u529b\u7814\u7a76\u7684\u91cd\u8981\u9818\u57df\u3002\u9019\u7576\u4e2d\u4ee5\u54c8\u4f5b\u5927\u5b78\u683c\u6797\u751f\u7269\u8001\u5316\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u8f9b\u514b\u840a\u6559\u6388\uff08Dr.Sinclair\uff09\u53ca\u660e\u5c3c\u8607\u9054\u6885\u7d04\u91ab\u5b78\u4e2d\u5fc3\u67ef\u514b\u6717\u6559\u6388\uff08Dr.Kirland\uff09\u7684\u7814\u7a76\u76f8\u7576\u5091\u51fa\uff0c\u76ee\u524d\u5df2\u6f38\u9732\u66d9\u5149\uff0c\u6709\u4e00\u4e9b\u85e5\u7269\u5df2\u9032\u5165\u7b2c\u4e00\u671f\u53ca\u7b2c\u4e8c\u671f\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u5728\u52d5\u7269\u5be6\u9a57\u5df2\u6709\u6210\u529f\u7684\u6848\u4f8b\u3002<\/p>\n\n\n\n

\u8fc4\u4eca\u70ba\u6b62\uff0c\u7d30\u80de\u8870\u8001\u5728\u7d30\u80de\u5167\u6709\u4e0d\u540c\u7684\u8a0a\u606f\u50b3\u905e\u8def\u5f91\uff0c\u4f8b\u5982\uff1a\uff081\uff09\u6297\u51cb\u4ea1\u9014\u5f91\uff08BCL\u5bb6\u65cf\uff09\u3001\uff082\uff09\u6297PI3K\u53ca\u76f8\u95dc\u6fc0\u9176\u9014\u5f91\u3001\uff083\uff09\u6297P53\u9014\u5f91\u3001\uff084\uff09\u6297NF-\u03baB\u9014\u5f91\u3001\uff085\uff09\u6297mTOR\u9014\u5f91\u3001\uff086\uff09\u6297JAK-STAT\u9014\u5f91\u3002\u9019\u4e9b\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u90fd\u6709\u5c0d\u61c9\u7684\u85e5\u7269\u53ca\u76f8\u95dc\u4eba\u9ad4\u81e8\u5e8a\u8a66\u9a57\uff0c\u9019\u4e9b\u6297\u8001\u85e5\u7269\uff0c\u7d71\u7a31\u300c\u8001\u5316\u88c2\u89e3\u7d20\u300d\uff08Senolytic\uff09\uff0c\u9019\u4e9b\u5c0f\u5206\u5b50\u85e5\u7269\u5c08\u8a2d\u7528\u4f86\u6bba\u6b7b\u8870\u8001\u7d30\u80de\uff0c\u8a98\u767c\u539f\u672c\u61c9\u8a72\u767c\u751f\u7684\u6b7b\u4ea1\u7a0b\u5f0f\u3002<\/p>\n\n\n\n

\u6700\u70ba\u986f\u8457\u4e14\u6210\u529f\u7684\u4f8b\u5b50\uff0c\u5c31\u662f\u67ef\u514b\u6717\u6559\u6388\u6240\u5b8c\u6210\u7528\u5169\u500b\u8001\u5316\u88c2\u89e3\u7d20\uff0c\u4e00\u7a2e\u662f\u69f2\u76ae\u7d20\uff08Quercetin\uff09\u53ef\u5728\u767d\u82b1\u6930\u83dc\u3001\u7fbd\u8863\u7518\u85cd\u548c\u7d05\u6d0b\u8525\u88e1\u627e\u5230\uff0c\u53e6\u4e00\u7a2e\u53eb\u67cf\u840a\uff08Dasatinib\uff09\u7684\u85e5\u7269\u5408\u7528\uff08\u6cbb\u7642\u767d\u8840\u75c5\u7684\u5316\u7642\u85e5\u7269\uff09\uff0c\u5169\u8005\u5408\u7528\u53ef\u4ee5\u4f7f\u58fd\u547d\u5ef6\u957736%\uff0c\u9019\u500b\u7814\u7a76\u610f\u7fa9\u975e\u5e38\u91cd\u5927\u3002\u82e5\u80fd\u767c\u63ee\u4f5c\u7528\uff0c\u53ea\u8981\u670d\u7528\u4e00\u9031\u4e00\u500b\u7642\u7a0b\u7684\u85e5\u7269\uff0c\u5c31\u80fd\u9006\u9f61\u8fd4\u6625\uff0c\u7136\u5f8c\u5341\u5e74\u5f8c\u518d\u670d\u7528\u53e6\u4e00\u7642\u7a0b\u5373\u53ef\uff0c\u90a3\u9ebc\u5ef6\u5e74\u76ca\u58fd\u4e0d\u518d\u662f\u5922\u60f3\uff0c\u53e6\u5916\u4e00\u7a2e\u65b9\u6cd5\u5c31\u662f\u6e90\u81ea\u5fa9\u6d3b\u7bc0\u5cf6\u7684\u9577\u58fd\u5206\u5b50\u96f7\u5e15\u9ef4\u7d20\uff08Rapamycin\uff09\uff0c\u7a31\u70ba\u300c\u6297\u8001\u578b\u614b\u5206\u5b50\u300d\uff08Senomorphic molecule\uff09\uff0c\u56e0\u70ba\u5b83\u7121\u6cd5\u6bba\u6b7b\u8870\u8001\u7d30\u80de\uff0c\u4f46\u53ef\u4ee5\u963b\u6b62\u8870\u8001\u7d30\u80de\u91cb\u653e\u6709\u5bb3\u7684\u767c\u708e\u5206\u5b50\uff0c\u4e5f\u540c\u6a23\u9054\u5230\u6297\u8001\u5316\u7684\u76ee\u7684\uff08\u5716\u4e94\uff09\u53ca\uff08\u5716\u516d\uff09\u3002<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n
\"\"<\/a><\/figure>\n\n\n\n

\u5728\u4e0a\u4e00\u7bc7Dr.Sinclair\u7684\u7814\u7a76\u5718\u968a\u5229\u7528\u8868\u89c0\u57fa\u56e0\u9ad4\u7684\u8a0a\u606f\u6307\u4ee4\uff0c\u6253\u958b\u4e09\u7a2e\u57fa\u56e0\uff08Oct4, Sox2, Klf4, \u7c21\u7a31OSK\uff09\u9001\u5165\u5e74\u8001\u5c0f\u9f20\u6709\u56b4\u91cd\u8996\u795e\u7d93\u53d7\u640d\u9752\u5149\u773c\u7684\u8996\u7db2\u819c\uff0c\u8996\u529b\u5e7e\u4e4e\u53ef\u4ee5\u5b8c\u5168\u6062\u5fa9\uff0c\u9019\u4e5f\u662f\u9006\u8f49\u8001\u5316\u7684\u53e6\u4e00\u767c\u5c55\u8da8\u52e2\u3002\u4ed6\u8a8d\u70ba\u8870\u8001\u7d30\u80de\u53ea\u662f\u7d30\u80de\u9031\u671f\u505c\u6eef\uff0c\u9084\u6c92\u6709\u5230\u6b7b\u4ea1\u968e\u6bb5\uff0c\u53ef\u4ee5\u900f\u904e\u8868\u89c0\u57fa\u56e0\u91cd\u65b0\u555f\u52d5\uff0c\u53ef\u4ee5\u9006\u8f49\u8001\u5316\u3002\u63db\u8a00\u4e4b\uff0c\u9006\u8f49\u8001\u5316\u7684\u65b9\u6cd5\u4ea6\u53ef\u91cd\u65b0\u555f\u52d5\u8868\u89c0\u57fa\u56e0\u6642\u9418\uff0c\u4ea6\u5373\u6240\u8b02DNA\u7684\u53bb\u7532\u57fa\u5316\uff0c\u9019\u4e5f\u662f\u9006\u9f61\u56de\u6625\u7684\u53e6\u4e00\u9014\u5f91\u3002<\/p>\n\n\n\n

\u7d50\u8a9e<\/strong><\/p>\n\n\n\n

\u8001\u5316\u662f\u4eba\u7684\u4e00\u751f\u7576\u4e2d\u4e0d\u53ef\u907f\u514d\u7684\u751f\u547d\u6b77\u7a0b\uff0c\u6709\u95dc\u8001\u5316\u7684\u6210\u56e0\u53ca\u4f5c\u7528\u6a5f\u8f49\u5728\u4e0a\u4e00\u7bc7\u5df2\u7d93\u8a73\u7d30\u4ecb\u7d39\u3002\u5982\u4f55\u5c0d\u6297\u8001\u5316\u7522\u751f\u7684\u554f\u984c\u975e\u5e38\u91cd\u8981\uff0c\u5982\u514d\u75ab\u529b\u4f4e\u4e0b\u3001\u7522\u751f\u7cd6\u5c3f\u75c5\u3001\u5fc3\u8840\u7ba1\u53ca\u795e\u7d93\u7cfb\u7d71\u7b49\u6162\u6027\u75be\u75c5\u4e43\u81f3\u764c\u75c7\uff0c\u5982\u4f55\u5c0d\u6297\u8001\u5316\u513c\u7136\u6210\u70ba\u91ab\u5b78\u754c\u8981\u9762\u5c0d\u7684\u56b4\u8085\u8ab2\u984c\u3002<\/p>\n\n\n\n

\u6e05\u9664\u8870\u8001\u7d30\u80de\u662f\u5c0d\u6297\u8001\u5316\u7684\u65b0\u7b56\u7565\uff0c\u53ef\u900f\u904e\u85e5\u7269\uff0c\u5373\u6240\u8b02\u8870\u8001\u7d30\u80de\u88c2\u89e3\u7d20\u6216\u8870\u8001\u7d30\u80de\u6eb6\u89e3\u85e5\u7269\uff08Senolytic drug\uff09\uff0c\u5b83\u53ef\u5c08\u4e00\u6027\u8a98\u5c0e\u8870\u8001\u7d30\u80de\u7522\u751f\u51cb\u4ea1\uff08apoptosis\uff09\u3002\u53e6\u4e00\u7a2e\u65b9\u6cd5\u662f\u53ef\u4f7f\u7528\u85e5\u7269\u6216\u5929\u7136\u690d\u7269\u4e4b\u8403\u53d6\u7269\u4f7f\u8870\u8001\u7d30\u80de\u7522\u751f\u7684\u5206\u6ccc\u56e0\u5b50\uff08\u6240\u8b02\u8870\u8001\u7d30\u80de\u6709\u95dc\u8868\u73fe\u578b\u5206\u6ccc\u56e0\u5b50,senescence associated secretory phenotype,SASP\uff09\u6e1b\u5c11\u6216\u964d\u4f4e\u81f3\u96f6\uff0c\u4f7f\u5176\u4e0d\u518d\u5f71\u97ff\u9031\u908a\u6b63\u5e38\u7d30\u80de\u8b8a\u6210\u8870\u8001\u7d30\u80de\uff0c\u6b64\u7a2e\u65b9\u6cd5\u53eb\u6291\u5236\u8001\u5316\u6216\u8870\u8001\u505c\u6eef\uff08Senostasis\uff09\uff0c\u4e5f\u5c31\u662f\u6240\u8b02\u6297\u8001\u578b\u614b\u5206\u5b50\uff08Senomorphics\uff09\u3002<\/p>\n\n\n\n

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\"\"<\/a><\/figure>","protected":false},"excerpt":{"rendered":"

In\u00a0the previous article, we mentioned the causes and mechanisms of action related to aging, and this article will specifically discuss some anti-aging methods and development trends. In fact, some medical therapies and life-prolonging technologies have existed around the world, but some will still take years or even decades to overcome. In the past few years, … <\/p>\n

\u7e7c\u7e8c\u95b1\u8b80 “Can cells be immortal? There are tips for fighting aging”<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"footnotes":""},"class_list":["post-2814","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/pages\/2814","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/comments?post=2814"}],"version-history":[{"count":5,"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/pages\/2814\/revisions"}],"predecessor-version":[{"id":2842,"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/pages\/2814\/revisions\/2842"}],"wp:attachment":[{"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/media?parent=2814"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}