{"id":612,"date":"2018-10-25T06:04:47","date_gmt":"2018-10-25T06:04:47","guid":{"rendered":"http:\/\/www.marseille-quince.com\/?page_id=612"},"modified":"2024-01-27T12:22:45","modified_gmt":"2024-01-27T12:22:45","slug":"egfbfgf","status":"publish","type":"page","link":"https:\/\/marseille-quince.com\/zh\/egfbfgf\/","title":{"rendered":"EGF + bFGF"},"content":{"rendered":"

\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50 (hEGF)<\/h3>\n

      \u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50 (hEGF) \u662f\u4e00\u7a2e\u5b58\u5728\u65bc\u5341\u4e8c\u6307\u8178\u548c\u553e\u6db2\u817a\u4e2d\u7684 53 \u500b\u80fa\u57fa\u9178\u591a\u80bd\uff08\u5716 1 \u548c 2\uff09\u3002 \u5b83\u80fd\u523a\u6fc0\u76ae\u819a\u8868\u76ae\u3001\u80c3\u8178\u9053\u3001\u89d2\u819c\u200b\u200b\u7b49\u591a\u7a2e\u8868\u76ae\u7d44\u7e54\u7684\u7d30\u80de\u589e\u751f\u548c\u5206\u5316\u3002<\/p>\n

\"\"<\/a><\/p>\n

 EGF\u65bc1960\u5e74\u7531\u65af\u5766\u5229\u00b7\u79d1\u6069\uff08Stanley Cohen\uff09\u9996\u6b21\u5f9e\u5c0f\u9f20\u981c\u4e0b\u817a\u4e2d\u5206\u96e2\u51fa\u4f86\uff0c\u4ed6\u56e0\u5c0dEGF\u7684\u767c\u73fe\u548c\u7814\u7a76\u65bc1986\u5e74\u7372\u5f97\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u548c\u91ab\u5b78\u734e\u3002 hEGF\u3002<\/p>\n

      hEGF \u589e\u5f37\u7684\u7652\u5408\u904e\u7a0b\u5728\u8a31\u591a\u61c9\u7528\u4e2d\u90fd\u6709\u8a73\u7d30\u8a18\u9304\u3002 \u5b83\u4f5c\u70ba\u4fc3\u9032\u5341\u4e8c\u6307\u8178\u6f70\u760d\u3001\u809d\u640d\u50b7\u548c\u773c\u640d\u50b7\u4fee\u5fa9\u7684\u6d3b\u6027\u6210\u5206\u3002 \u5b83\u53ef\u4ee5\u6700\u5927\u9650\u5ea6\u5730\u6e1b\u5c11\u8f38\u5c3f\u7ba1\u963b\u585e\u7684\u5f71\u97ff\uff0c\u5354\u52a9\u795e\u7d93\u7d44\u7e54\u7684\u518d\u751f\u4e26\u589e\u5f37\u6297\u764c\u85e5\u7269\u7684\u4f5c\u7528\u3002<\/p>\n

\u5176\u5f71\u97ff\u5df2\u64f4\u5c55\u5230\u5546\u696d\u9818\u57df\u3002 GVN \u63d0\u4f9b\u7684\u88dc\u5145\u6709 hEGF \u7684\u5316\u599d\u54c1\u548c\u4fdd\u990a\u54c1\uff08\u5716 3 \u548c 4\uff09\u80fd\u5920\u4f7f\u76ae\u819a\u8868\u76ae\u518d\u751f\u3002 \u5b83\u53ef\u4ee5\u6539\u5584\u76ae\u819a\u7684\u8cea\u5730\u548c\u72c0\u6cc1\u3002 \u6700\u91cd\u8981\u7684\u662f\uff0c\u5b83\u901a\u904e\u4e86\u5b89\u5168\u6e2c\u8a66\u3001\u6bd2\u6027\u6e2c\u8a66\u3001\u904e\u654f\u6e2c\u8a66\uff0c\u6c92\u6709\u4e0d\u826f\u53cd\u61c9\u7684\u5831\u544a\u3002<\/p>\n

\"\"<\/a>\n<\/p>\n

\u9e7c\u6027\u7e96\u7dad\u7d30\u80de\u751f\u9577\u56e0\u5b50 (bFGF)<\/h3>\n

\u9e7c\u6027\u7e96\u7dad\u7d30\u80de\u751f\u9577\u56e0\u5b50\uff0c\u4e5f\u7a31\u70ba bFGF \u6216 FGF2\uff08\u5716 5\uff09\uff0c\u662f\u7e96\u7dad\u6bcd\u7d30\u80de\u751f\u9577\u56e0\u5b50\u5bb6\u65cf\u7684\u6210\u54e1\u3002 \u4eba\u985e bFGF (hbFGF) \u662f\u4e00\u7a2e 16.2 kDa \u7684\u591a\u80bd\uff0c\u542b\u6709 146 \u500b\u80fa\u57fa\u9178\uff0c\u5b58\u5728\u65bc\u8840\u7ba1\u7684\u5167\u76ae\u4e0b\u7d30\u80de\u5916\u57fa\u8cea\u548c\u57fa\u5e95\u819c\u4e2d\u3002<\/p>\n

bFGF\u7684\u529f\u80fd\u4e4b\u4e00\u662f\u4fc3\u9032\u5167\u76ae\u7d30\u80de\u589e\u751f\u3002 \u5b83\u4ecb\u5c0e\u8840\u7ba1\u751f\u6210\u904e\u7a0b\uff0c\u5373\u5f9e\u9810\u5148\u5b58\u5728\u7684\u8108\u7ba1\u7cfb\u7d71\u4e2d\u751f\u9577\u51fa\u8840\u7ba1\u3002 \u5b83\u767c\u751f\u5728\u5065\u5eb7\u7684\u8eab\u9ad4\u4e2d\uff0c\u7528\u65bc\u7652\u5408\u50b7\u53e3\u4e26\u6062\u5fa9\u53d7\u50b7\u5f8c\u7d44\u7e54\u7684\u8840\u6db2\u6d41\u52d5\u3002<\/p>\n

\u6b64\u5916\uff0cbFGF\u4e5f\u53c3\u8207\u7d44\u7e54\u4fee\u5fa9\u3002 \u5b83\u523a\u6fc0\u7e96\u7dad\u6bcd\u7d30\u80de\u589e\u6b96\uff0c\u7522\u751f\u8089\u82bd\u7d44\u7e54\uff0c\u5728\u50b7\u53e3\u7652\u5408\u904e\u7a0b\u4e2d\u586b\u5145\u50b7\u53e3\u7a7a\u9593\u3002 \u4e0d\u50c5\u7e2e\u77ed\u4e86\u6062\u5fa9\u6642\u9593\uff0c\u800c\u4e14\u63d0\u9ad8\u4e86\u50b7\u53e3\u7652\u5408\u7684\u54c1\u8cea\u3002<\/p>\n

\u5728 Dr. Cocco Lab\uff0c\u6211\u5011\u4f7f\u7528\u4e0d\u540c\u7684\u7d30\u83cc\u5bbf\u4e3b\u7cfb\u7d71\u4f86\u8868\u73fe\u91cd\u7d44 hbFGF\u3002 \u6b63\u5728\u9032\u884c\u4ee5\u5177\u6709\u6210\u672c\u6548\u76ca\u7684\u50f9\u683c\u5927\u898f\u6a21\u751f\u7522 hbFGF \u7684\u5de5\u4f5c\u3002<\/p>\n

\"\"<\/a>\n<\/p>\n

\"\"<\/a><\/h3>\n\n\n
<\/div>\n\n\n\n


EGF + BFGF + HA <\/h2>\n\n\n\n

\u638c\u63e1\u4e09\u5927\u95dc\u9375\u6297\u8001\u4fdd\u6fd5\u5143\u7d20\uff0c\u9996\u5275Biotechnology DNA\u91ab\u5b78\u5c08\u5229\u79d1\u6280\uff0c\u7d50\u54082000IU\u6d3b\u6027\u55ae\u4f4d\u57fa\u56e0\u91cd\u7d44EGF\u3001bFGF\u751f\u9577\u56e0\u5b50\u9664\u76ba\u914d\u65b9\uff0c\u4e26\u6dfb\u52a0\u6210\u4efd\u5929\u7136\u7684HA\u73bb\u5c3f\u9178\u4fdd\u6fd5\u56e0\u5b50\uff0c\u70ba\u808c\u819a\u6301\u7e8c\u88dc\u6c34\u53ca\u5efa\u7acb\u5f37\u6548\u7684\u9396\u6c34\u5c4f\u969c\uff0c\u540c\u6642\u6df1\u5165\u808c\u819a\u5f37\u5316\u7d30\u80de\u589e\u751f\u529b\u91cf\uff0c\u9810\u9632\u81a0\u539f\u86cb\u767d\u65b7\u88c2\uff0c\u62b5\u79a6\u8001\u5316\u7d30\u80de\uff0c\u5feb\u901f\u4fee\u5fa9\u76ba\u7d0b\u53ca\u75a4\u75d5\uff0c\u559a\u8d77\u5e74\u8f15\u7d30\u80de\u7684\u518d\u751f\u529f\u80fd\uff0c\u5168\u9762\u518d\u9020\u5e74\u8f15\u5149\u611f\u808c\u819a\u3002<\/p>\n\n\n\n

\"\"<\/a><\/figure><\/div>\n\n\n\n

\u4ec0\u9ebc\u662fEGF\uff1f<\/h2>\n\n\n\n
\"\"<\/a><\/figure><\/div>\n\n\n\n

EGF\uff08Epidermal Growth Factor\uff09\u5b78\u540d\u201c\u8868\u76ae\u7d30\u80de\u751f\u9577\u56e0\u5b50\u201d\uff0c\u662f\u4eba\u9ad4\u5167\u5206\u6ccc\u7684\u4e00\u7a2e\u91cd\u8981\u7d30\u80de\u751f\u9577\u56e0\u5b50\uff0c\u6709\u5f88\u5f37\u7684\u751f\u7406\u6d3b\u6027\uff0c\u5b83\u7684\u4e3b\u8981\u529f\u80fd\u662f\u4fc3\u9032\u76ae\u819a\u7d30\u80de\u7684\u5206\u88c2\u3002<\/p>\n\n\n\n

1962\u5e74\uff0c\u7f8e\u570b\u79d1\u5b78\u5bb6Cohen\u535a\u58eb\u767c\u73fe\u4e86\u6c7a\u5b9a\u76ae\u819a\u5e74\u9f61\u7684\u201c\u8868\u76ae\u751f\u9577\u56e0\u5b50\u201dEGF\uff0c\u4e26\u9032\u4e00\u6b65\u8b49\u5be6\uff1aEGF\u7684\u7f3a\u5931\uff0c\u662f\u5c0e\u81f4\u76ae\u819a\u8870\u8001\u7684\u6839\u672c\u539f\u56e0\u3002\u9019\u9805\u5049\u5927\u7684\u767c\u73fe\uff0c\u4f7fCohen\u535a\u58eb\u65bc1986\u5e74\u6210\u70ba\u8afe\u8c9d\u723e\u91ab\u5b78\u53ca\u751f\u7406\u734e\u5f97\u4e3b\u3002\u4ed6\u7684\u7814\u7a76\u7406\u8ad6\u8868\u660e\u7d66\u76ae\u819a\u88dc\u5145EGF\uff0c\u53ef\u4ee4\u8870\u8001\u76ae\u819a\u56de\u5fa9\u5e74\u8f15\u7dca\u7dfb\uff0c\u6975\u5fae\u91cf\u7684EGF\u5373\u80fd\u4fc3\u9032\u53ca\u523a\u6fc0\u7d30\u80de\u751f\u9577\uff0c\u6709\u6548\u6291\u5236\u8870\u8001\u57fa\u56e0\uff0c\u5ef6\u7de9\u76ae\u819a\u8870\u8001\uff0c\u4f7f\u76ae\u819a\u5404\u7d44\u6210\u4efd\u4fdd\u6301\u6700\u4f73\u751f\u7406\u72c0\u614b\u3002\u6b64\u5916\uff0cEGF\u9084\u80fd\u523a\u6fc0\u7d30\u80de\u5916\u4e00\u4e9b\u5927\u5206\u5b50\uff08\u5982\u900f\u660e\u8cea\u9178\u548c\u81a0\u539f\u86cb\u767d\u7b49\uff09\u7684\u5408\u6210\u8207\u5206\u6ccc\uff0c\u6ecb\u6f64\u76ae\u819a\uff0c\u662f\u6c7a\u5b9a\u76ae\u819a\u6d3b\u529b\u548c\u5065\u5eb7\u7684\u95dc\u9375\u56e0\u7d20\u3002\u5f9e\u6b64\uff0c\u76ae\u819a\u5e74\u8f15\u8207\u8870\u8001\u7684\u5967\u79d8\u88ab\u63ed\u958b\uff0c\u4eba\u985e\u91cd\u73fe\u5e74\u8f15\u7684\u5922\u60f3\u8b8a\u6210\u73fe\u5be6\u3002<\/p>\n\n\n\n

<\/a><\/h3>\n\n\n\n

\u4ec0\u9ebc\u662fbFGF\uff1f<\/h2>\n\n\n\n
\"\"<\/a><\/figure><\/div>\n\n\n\n

bFGF\uff08basic fibroblast growth factor\uff09\u53c8\u540d\u201c\u9e7c\u6027\u6210\u7e96\u7dad\u7d30\u80de\u751f\u9577\u56e0\u5b50\u201d\uff0c\u662f\u4e00\u7a2e\u591a\u6548\u80fd\u7684\u7d30\u80de\u751f\u9577\u56e0\u5b50\uff0c\u5ee3\u6cdb\u4f5c\u7528\u65bc\u4e2d\u80da\u5c64\u548c\u795e\u7d93\u5916\u80da\u5c64\u4f86\u6e90\u7684\u7d44\u7e54\u548c\u7d30\u80de\u3002\u5b83\u80fd\u4fc3\u9032\u76ae\u819a\u771f\u76ae\u5c64\u5167\u7684\u6210\u7e96\u7dad\u7d30\u80de\u5206\u88c2\u589e\u6b96\uff0c\u4fee\u5fa9\u8001\u5316\u640d\u50b7\u7684\u771f\u76ae\u5c64\u7d44\u7e54\uff0c\u6062\u5fa9\u808c\u819a\u5f48\u6027\u7e96\u7dad\u7d50\u69cb\uff0c\u65bc\u77ed\u6642\u9593\u5167\u6539\u5584\u76ae\u819a\u9b06\u5f1b\u3001\u76ba\u7d0b\u3001\u75a4\u75d5\u3001\u6697\u6c89\u7b49\u554f\u984c\uff0c\u6062\u5fa9\u808c\u819a\u5f48\u6027\u3002  bFGF\u7684\u53e6\u4e00\u9805\u91cd\u8981\u529f\u80fd\u662f\u4fc3\u8840\u7ba1\u751f\u6210\u4f5c\u7528\uff0c\u80fd\u4f7f\u8da8\u5316\u8840\u7ba1\u5167\u819c\u5404\u985e\u7d30\u80de\uff0c\u523a\u6fc0\u5176\u589e\u6b96\u548c\u9077\u79fb\uff0c\u5f9e\u800c\u4ee4\u76ae\u819a\u7d44\u7e54\u5feb\u901f\u751f\u6210\u65b0\u8840\u7ba1\uff0c\u8c50\u5bcc\u76ae\u4e0b\u8840\u6db2\u5fae\u5faa\u74b0\u7cfb\u7d71\uff0c\u71df\u990a\u76ae\u819a\u7d44\u7e54\u3002bFGF\u4e5f\u662f\u4e00\u7a2e\u795e\u7d93\u71df\u990a\u56e0\u5b50\uff0c\u5c0d\u76ae\u4e0b\u795e\u7d93\u7d44\u7e54\u5177\u6709\u4fc3\u9032\u751f\u9577\u5206\u5316\u3001\u7dad\u6301\u5b58\u6d3b\u7684\u4f5c\u7528\uff0c\u63d0\u9ad8\u76ae\u819a\u5c0d\u5916\u754c\u4e0d\u826f\u4fb5\u64fe\u56e0\u7d20\u7684\u611f\u77e5\u80fd\u529b\uff0c\u589e\u5f37\u76ae\u819a\u62b5\u79a6\u80fd\u529b\u3002<\/p>\n\n\n\n

*\u88dc\u5145\uff1a\u7e96\u7dad\u6bcd\u7d30\u80de\u751f\u9577\u56e0\u5b50(Fibroblast Growth factor\uff1bFGF)\u6700\u521d\u662f\u5f9e\u725b\u7684\u8166\u4e0b\u5782\u9ad4(bovine pituitary gland)\u4e2d\u8403\u53d6\u7d14\u5316\u6240\u5f97\u5230\u7684\uff0c\u7531\u65bc\u80fd\u4fc3\u9032\u7e96\u7dad\u6bcd\u7d30\u80de\u682a NIH3T3cells \u589e\u751f\uff0c\u6240\u4ee5\u7531\u6b64\u547d\u540d\u3002<\/p>\n\n\n\n

\u5f9e 1970 \u5e74\u6642\u7d14\u5316\u51fa aFGF (FGF-1)\u81f3\u4eca\u6578\u5341\u5e74\u9593\uff0c\u9084\u6709\u4e0d\u540c\u7684 FGFs \u88ab\u767c\u73fe\uff0c\u5206\u5225\u70ba\uff1aFGF-1 (aFGF)\u3001FGF-2 (bFGF)\u3001FGF-3 (INT-2)\u3001FGF-4(HST-1)\u3001FGF-5\u3001FGF-6 (HST-2)\u3001FGF-7 (KGF)\u3001FGF-8 (AIGF)\u3001FGF-9 (GGF)\u3001FGF-10\u3001FGF-11 (FHF-3)\u3001FGF-12 (FHF-1)\u3001FGF-13 (FHF-2)\u3001FGF-14 (FHF-4)\u53caFGF-15 \u7b49\u5341\u4e94\u7a2e\uff0c\u9019\u4e9b\u7a31\u4e4b\u70ba\u7e96\u7dad\u6bcd\u7d30\u80de\u751f\u9577\u56e0\u5b50\u5bb6\u65cf(FGF family)\uff0c\u5176\u5171\u901a\u6027\u5c31\u662f\u69cb\u9020\u4e0a\u5177\u6709 heparin binding domain\uff0c\u6240\u4ee5\u53c8\u88ab\u7a31\u4e4b\u70ba heparin binding growth factor(HBGF)\u3002<\/p>\n\n\n\n

\u7d93\u7814\u7a76\u6307\u51fa\uff0cFGFs \u6709\u8abf\u7bc0\u7d30\u80de\u751f\u9577(growth)\u3001\u5b58\u6d3b(survival)\u3001\u5206\u5316(differentiation)\u548c\u9077\u5f99(migration)\u7b49\u529f\u7528(Rider et al., 1995)\u3002\u4e14\u57fa\u5c64\u7e96\u7dad\u6bcd\u7d30\u80de\u751f\u9577\u56e0\u5b50\u523a\u6fc0\u5f88\u591a\u7a2e\u7d30\u80de\u751f\u9577\uff0c\u4e26\u4e14\u5177\u6709\u5f37\u529b\u65b0\u8840\u7ba1\u589e\u751f\u7684\u523a\u6fc0\u80fd\u529b\uff0c\u540c\u6642\u53ef\u4ee5\u523a\u6fc0\u81a0\u539f\u86cb\u767d\u4ee5\u53ca\u5f48\u529b\u86cb\u767d\u7684\u81ea\u7136\u5408\u6210\uff0c\u589e\u5f37\u76ae\u819a\u5f48\u6027\u4e26\u6e1b\u5c11\u76ba\u7d0b\u3002\u6b64\u5916\u57fa\u5c64\u7e96\u7dad\u6bcd\u7d30\u80de\u751f\u9577\u56e0\u5b50\u4e5f\u662f\u50b7\u53e3\u7652\u5408\u904e\u7a0b\u7684\u91cd\u8981\u751f\u9577\u56e0\u5b50\u3002\u5176\u4e3b\u8981\u529f\u80fd\u5982\u4e0b\uff1a\u76ae\u819a\u518d\u751f\u3001\u523a\u6fc0\u81a0\u539f\u86cb\u767d\u53ca\u5f48\u529b\u86cb\u767d\u5408\u6210\u3001\u523a\u6fc0\u7e96\u7dad\u6bcd\u7d30\u80de\u751f\u9577\u3001\u523a\u6fc0\u8001\u5316\u7d44\u7e54\u518d\u751f\u4ee5\u53ca\u50b7\u53e3\u7652\u5408\u3001\u523a\u6fc0\u8868\u76ae\u7d30\u80de\u751f\u9577\u53ca\u79fb\u52d5\u3001\u523a\u6fc0\u6bdb\u9aee\u751f\u9577\uff0c\u9632\u6b62\u767d\u982d\u9aee\u5f62\u6210\u53ca\u523a\u6fc0\u73bb\u5c3f\u9178\u5408\u6210\u3002\u6839\u64da\u4ee5\u5f80\u7684\u7814\u7a76\uff0cbFGF \u5177\u6709\u4fc3\u9032\u9ad4\u5916\u57f9\u990a\u4e4b\u8840\u7ba1\u5e73\u6ed1\u808c\u7d30\u80de\u751f\u9577\u7684\u4f5c\u7528\uff0c\u6709\u4fc3\u9032\u8840\u7ba1\u65b0\u751f\u3001\u8840\u6db2\u5faa\u74b0\u53ca\u4fc3\u9032\u81a0\u539f\u65b0\u751f\u7684\u529f\u80fd\uff0c\u548c\u4fc3\u9032\u7d30\u80de\u81ea\u7136\u7684\u50b7\u53e3\u5fa9\u539f\u6a5f\u5236\u3002<\/p>\n\n\n\n

EGF\u3001bFGF\u65e9\u671f\u61c9\u7528\u53ca\u751f\u7522\u96e3\u5ea6<\/h2>\n\n\n\n

EGF\u3001bFGF\u5747\u662f\u4eba\u9ad4\u5167\u7684\u91cd\u8981\u7d30\u80de\u751f\u9577\u56e0\u5b50\uff0c\u80fd\u6709\u6548\u4fc3\u9032\u7d30\u80de\u751f\u9577\u53ca\u523a\u6fc0\u4eba\u9ad4\u4fee\u5fa9\u6a5f\u80fd\uff0c\u56e0\u6b64\u65e9\u671f\u88ab\u61c9\u7528\u65bc\u6cbb\u7642\u76ae\u708e\u3001\u71d2\u50b7\u3001\u71d9\u50b7\u3001\u76ae\u819a\u5916\u50b7\u3001\u8853\u5f8c\u5275\u53e3\u3001\u89d2\u819c\u640d\u50b7\u3001\u53e3\u8154\u6f70\u760d\u3001\u80c3\u6f70\u760d\u3001\u8925\u7621\u3001\u58de\u75bd\u7b49\uff0c\u8207\u5275\u50b7\u4fee\u5fa9\u3001\u50b7\u53e3\u7652\u5408\u6709\u95dc\u7684\u91ab\u5b78\u9818\u57df\u4e0a\u30021992\u5e74\uff0c\u7f8e\u570b\u8a79\u59c6\u58eb\u85e5\u7269\u5be6\u9a57\u5ba4\u5617\u8a66\u5c07EGF\u6dfb\u52a0\u5230\u5316\u599d\u54c1\u4e2d\uff0cEGF\u80fd\u4fc3\u9032\u8868\u76ae\u7d30\u80de\u7d44\u7e54\u5167\u591a\u7a2e\u7d30\u80de\u7684\u751f\u9577\u5206\u88c2\uff0c\u4f7f\u8868\u76ae\u7d30\u80de\u8b8a\u5f97\u98fd\u6eff\uff0c\u53ca\u523a\u6fc0\u81a0\u539f\u86cb\u767d\u751f\u9577\u80fd\u529b\uff0c\u5728\u6536\u7e2e\u6bdb\u5b54\u3001\u88aa\u76ba\u6297\u8870\u65b9\u9762\u6709\u5341\u5206\u986f\u8457\u529f\u7528\uff0c\u6240\u4ee5\u5728\u7576\u6642\u5099\u53d7\u611b\u7f8e\u4eba\u58eb\u8ffd\u6367\uff0c\u4e26\u8b7d\u4e4b\u70ba\u201c\u7f8e\u9e97\u56e0\u5b50\u201d\u3002\u7136\u800c\uff0c\u6642\u81f3\u4eca\u5929\uff0cEGF\u548cbFGF\u4ecd\u672a\u5ee3\u6cdb\u61c9\u7528\u65bc\u7f8e\u5bb9\u7522\u54c1\u4e2d\uff0c\u7b87\u4e2d\u6d89\u53ca\u4e86\u5169\u5927\u751f\u7522\u96e3\u984c\uff1a<\/p>\n\n\n\n

  1. \u63d0\u53d6\u56f0\u96e3\uff1aEGF\u548cbFGF\u662f\u5929\u7136\u7684\u8868\u76ae\u751f\u9577\u56e0\u5b50\uff0c\u4f46\u662f\u9019\u7a2e\u5929\u7136\u7684\u56e0\u5b50\u537b\u96e3\u4ee5\u5927\u898f\u6a21\u751f\u7522\u7684\u3002\u65e9\u671f\u7684EGF\u548cbFGF\u4e3b\u8981\u5f9e\u80ce\u76e4\u3001\u9ad4\u6db2\u4e2d\u63d0\u53d6\u800c\u6210\uff0c\u4f46\u7531\u65bc\u7576\u4e2d\u7684\u542b\u91cf\u6975\u4f4e\uff0c1\u842c\u500b\u80ce\u76e4\u5927\u7d04\u53ea\u53ef\u63d0\u53d61\u514bEGF\u6216bFGF\uff0c\u5c0e\u81f4\u751f\u9577\u56e0\u5b50\u5275\u4e0b\u4e86\u6bcf\u514b\u552e\u50f9200\u842c\u7f8e\u5143\u7684\u5929\u50f9\u50b3\u5947\u3002<\/li><\/ol>\n\n\n\n

    2. \u9700\u8981\u6975\u9ad8\u7684\u4fdd\u5b58\u6280\u8853\uff1aEGF\u548cbFGF\u4e00\u7a2e\u751f\u7269\u6d3b\u6027\u86cb\u767d\u8cea\uff0c\u82e5\u5931\u53bb\u6d3b\u6027\u5247\u7121\u6cd5\u767c\u63ee\u5176\u61c9\u6709\u7684\u4f5c\u7528\u3002\u7531\u65bc\u65e9\u671f\u7684\u4fdd\u5b58\u5de5\u85dd\u4e0d\u6210\u719f\uff0c\u5c0e\u81f4\u751f\u9577\u56e0\u5b50\u7684\u6d3b\u6027\u4fdd\u5b58\u671f\u53ea\u6709\u77ed\u77ed\u76847 \u2013 10\u5929\u6642\u9593\uff0c\u5927\u5927\u589e\u52a0 \u4e86\u5728\u7f8e\u5bb9\u7522\u54c1\u4e0a\u7684\u61c9\u7528\u96e3\u5ea6\u3002<\/p>\n\n\n\n

    \u5c08\u6ce8\u79d1\u7814\uff0c\u653b\u514b\u96e3\u95dc<\/h2>\n\n\n\n

    \u6211\u5011\u7522\u54c1\u6240\u4f7f\u7528\u7684\u751f\u9577\u56e0\u5b50\uff0c\u662f\u7d93\u904e\u57fa\u56e0\u91cd\u7d44\u7684rhEGF\u548crhbFGF\u3002rh\u8868\u793a\u7d50\u69cb\u6539\u9020\u7684\u610f\u601d\uff0c\u9019\u662f\u76ee\u524d\u5728\u91ab\u5b78\u754c\u6700\u5c16\u7aef\u53ca\u6700\u5177\u7a81\u7834\u6027\u7684\u751f\u7269\u79d1\u6280\u6280\u8853\u3002\u6211\u5011\u63a1\u7528\u5206\u6ccc\u578b\u8868\u9054\u7684\u5927\u8178\u687f\u83cc\u57fa\u56e0\u5de5\u7a0b\uff0c\u57f9\u990a\u4e26\u7372\u5f97\u8207\u4eba\u9ad4\u540c\u6e90\uff0c\u57fa\u56e0\u4e00\u81f4\u7684\u9ad8\u7d14\u5ea6rhEGF\u548crhbFGF\u3002\u53c8\u901a\u904e\u767c\u9175\uff0c\u7d14\u5316\uff0c\u771f\u7a7a\u51cd\u4e7e\u7b49\u751f\u7269\u5de5\u7a0b\u6280\u8853\uff0c\u5728\u4e0d\u6dfb\u52a0\u5316\u5b78\u6210\u5206\u7684\u60c5\u6cc1\u4e0b\uff0c\u88fd\u4f5c\u51fa\u542brhEGF\u53carhbFGF\u7684\u8b77\u819a\u7522\u54c1\uff0c\u4e14\u4fdd\u7559\u4e86\u539f\u6709\u7684\u6d3b\u6027\uff0c\u540c\u6642\u6eff\u8db3\u5927\u773e\u5c0d\u54c1\u8cea\u8207\u7d14\u5ea6\u7684\u8981\u6c42\u3002\u6211\u5011\u672c\u7740\u300c\u7cbe\u76ca\u6c42\u7cbe\uff0c\u52d9\u5be6\u5275\u65b0\u300d\u7684\u614b\u5ea6\uff0c\u7d50\u5408\u56b4\u683c\u7684\u54c1\u8cea\u76e3\u63a7\u7cfb\u7d71\uff0c\u81f4\u529b\u751f\u7522\u51fa\u54c1\u8cea\u512a\u826f\u3001\u9ad8\u6d3b\u6027\u53ca\u9ad8\u7d14\u5ea6\u7684rhEGF\u548crhbFGF\uff0c\u6301\u7e8c\u767c\u5c55\u88aa\u76ba\u6297\u8870\u7684\u751f\u7269\u7f8e\u5bb9\u65b0\u9818\u57df\uff0c\u671f\u5f85\u898b\u8b49\u751f\u7269\u57fa\u56e0\u7f8e\u5bb9\u6642\u4ee3\u7684\u5230\u4f86\u3002<\/p>\n\n\n\n

    rhEGF\u3001rhbFGF\u529f\u6548\u4ecb\u7d39<\/h2>\n\n\n\n

    \u6211\u5011\u7684\u8b77\u819a\u54c1\u6dfb\u52a0\u4e86\u9ad8\u7d14\u5ea6\u7684rhEGF\u548crhbFGF\u6210\u4efd\uff0c\u64c1\u6709\u4e0b\u5217\u4e94\u5927\u8b77\u819a\u529f\u6548\uff1a<\/h3>\n\n\n\n

    1\u3001\u9ad8\u6548\u4fee\u5fa9<\/h3>\n\n\n\n

    EGF\u3001bFGF\u80fd\u4fc3\u9032\u8868\u76ae\u7d30\u80de\u589e\u6b96\u5206\u5316\uff0c\u4f7f\u8870\u8001\u6b7b\u4ea1\u7684\u7d30\u80de\u5f97\u4ee5\u53ca\u6642\u88dc\u5145\uff0c\u4f7f\u640d\u50b7\u7684\u8868\u76ae\u5f97\u4ee5\u5373\u6642\u4fee\u5fa9\uff0c\u53ef\u7528\u65bc\u5c0d\u63db\u819a\u3001\u892a\u7d05\u3001\u6bdb\u7d30\u8840\u7ba1\u64f4\u5f35\u7b49\u5404\u7a2e\u4e0d\u826f\u819a\u8cea\u7684\u8abf\u6574\uff0c\u6539\u5584\u808c\u819a\u8584\u3001\u7c97\u7cd9\u3001\u75a4\u75d5\u7b49\u4e0d\u826f\u72c0\u6cc1\uff0c\u4f7f\u808c\u819a\u6062\u5fa9\u5149\u6f54\u548c\u5e73\u6ed1\u3002\u5404\u751f\u9577\u56e0\u6578\u4e3b\u52d5\u8207\u50b7\u53e3\u9644\u8fd1\u7d30\u80de\u819c\u4e0a\u7684\u7279\u7570\u6027\u53d7\u9ad4\u76f8\u7d50\u5408\uff0c\u5f9e\u800c\u555f\u52d5\u86cb\u767d\u9176\uff0c\u52a0\u5feb\u86cb\u767d\u8cea\u7684\u5408\u6210\uff0c\u4fc3\u9032\u6210\u7e96\u7dad\u7d30\u80de\u7684\u751f\u9577\uff0c\u4fc3\u9032\u76ae\u819a\u548c\u7c98\u819c\u5275\u9762\u7652\u5408\u4e26\u990a\u6d3b\u75a4\u75d5\u6536\u7e2e\u548c\u76ae\u819a\u7684\u7578\u5f62\u589e\u751f\uff0c\u5feb\u901f\u9ad8\u6548\u4fee\u5fa9\u5275\u50b7\u3002\u61c9\u7528\u65bc\u76ae\u819a\u7d44\u7e54\u7684\u5404\u7a2e\u640d\u50b7\uff0c\u53bb\u9664\u6697\u7621\u3001\u75e4\u7621\u3001\u53bb\u75e3\u5f8c\u7684\u5c0f\u7f3a\u640d\uff0c\u63db\u819a\u5f8c\u7684\u812b\u76ae\u3001\u767c\u7d05\u4ee5\u53ca\u679c\u9178\u7b49\u4f7f\u7528\u5f8c\u5c0e\u81f4\u7684\u76ae\u819a\u707c\u50b7\u3001\u78e8\u524a\u5f8c\u7684\u8868\u76ae\u640d\u50b7\u4fee\u5fa9\u7b49\u5177\u6709\u7a81\u51fa\u7684\u6548\u679c\u3002<\/p>\n\n\n\n

    2\u3001\u6d88\u9664\u76ba\u7d0b<\/h3>\n\n\n\n

    EGF\u3001bFGF\u5177\u6709\u4fc3\u9032\u6210\u7e96\u7dad\u7d30\u80de\u3001\u8868\u76ae\u7d30\u80de\u4ee3\u8b1d\u3001\u589e\u6b96\u548c\u751f\u9577\uff0c\u4fc3\u9032\u5f48\u6027\u7e96\u7dad\u7d30\u80de\u7684\u767c\u80b2\u7b49\u529f\u80fd\uff0c\u6709\u52a9\u555f\u52d5\u8001\u5316\u7d30\u80de\u7684\u518d\u751f\uff0c\u52a0\u901f\u7d30\u80de\u7684\u65b0\u9673\u4ee3\u8b1d\u548c\u66f4\u65b0\uff0c\u5feb\u901f\u4ee3\u8b1d\u8001\u5316\u89d2\u8cea\uff0c\u4fee\u5fa9\u65b7\u88c2\u7684\u6dfa\u8868\u76ae\u6210\u7e96\u7dad\u7d30\u80de\uff0c\u5f9e\u800c\u6d88\u9664\u76ba\u7d0b\u3002\u901a\u904eEGF\u3001bFGF\u6d3b\u6027\u56e0\u6578\u4fc3\u9032\u771f\u76ae\u5c64\u5167\u7e96\u7dad\u6bcd\u7d30\u80de\u7684\u589e\u6b96\uff0c\u4fee\u5fa9\u8001\u5316\u7684\u81a0\u539f\u7e96\u7dad\u8207\u5f48\u6027\u7e96\u7dad\uff1b\u66f4\u591a\u5730\u5408\u6210\u548c\u5206\u6ccc\u81a0\u539f\u86cb\u767d\u3001\u900f\u660e\u8cea\u9178\u7b49\u5927\u5206\u5b50\uff1b\u6539\u5584\u76ae\u819a\u5fae\u5faa\u74b0\uff0c\u63d0\u4f9b\u826f\u597d\u7684\u71df\u990a\u74b0\u5883\uff0c\u7dad\u6301\u4e00\u5b9a\u91cf\u7684\u76ae\u819a\u8102\u80aa\uff0c\u9084\u539f\u808c\u819a\u5f48\u6027\uff0c\u4f7f\u5176\u5747\u52fb\u7dca\u81f4\uff0c\u6e1b\u5c11\u76ba\u7d0b\u3002<\/p>\n\n\n\n

    3\u3001\u6297\u8870\u8001<\/h3>\n\n\n\n

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    4\u3001\u6de1\u5316\u8272\u6591<\/h3>\n\n\n\n

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    5\u3001\u6ecb\u6f64\u88dc\u6fd5<\/h3>\n\n\n\n

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    \u9664EGF\u548cbFGF\u5916\uff0c\u7522\u54c1\u9084\u52a0\u5165\u4e86\u4fdd\u6fd5\u529b\u6975\u9ad8\u7684\u73bb\u5c3f\u9178\uff0c\u4ee4\u8b77\u819a\u914d\u65b9\u66f4\u81fb\u5b8c\u7f8e\u3002<\/strong><\/h3>\n\n\n\n
    \"\"<\/a><\/figure><\/div>\n\n\n\n

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    \u9632\u7c89\u523a\u3001\u53bb\u75a4\u75d5\u4f5c\u7528<\/p>\n\n\n\n

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    \u4e26\u4fc3\u9032\u5275\u50b7\u7652\u5408\u8207\u7d44\u7e54\u4fee\u5fa9\uff0c\u540c\u6642\u589e\u751f\u591a\u5143\u5316\u6f5b\u80fd\u5e79\u7d30\u80de\uff0c\u6700\u7d42\u6709\u52a9\u795e\u7d93\u5143\u76ae\u8cea\u751f\u9577\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u80fd\u5920\u4fc3\u9032\u771f\u76ae\u5c64\u9e7c\u6027\u6210\u7e96\u7dad\u6bcd\u7d30\u80de\u548c\u9e7c\u6027\u6210\u7e96\u7dad\u7d30\u80de\u5206\u88c2\uff0c\u5f9e\u800c\u4fc3\u9032\u81a0\u539f\u86cb\u767d\u548c\u5f48\u529b\u86cb\u767d\u7684\u5f62\u6210\uff0c\u589e\u5f37\u76ae\u819a\u7684\u5f48\u6027\uff0c\u80fd\u4fc3\u9032\u795e\u7d93\u7d30\u80de\u5206\u88c2\u589e\u751f\u7e41\u6b96\uff0c\u4f7f\u808c\u819a\u5145\u6eff\u6d3b\u529b\uff0c\u9084\u80fd\u4fc3\u9032\u6bdb\u7d30\u8840\u7ba1\u7684\u5f62\u6210\u548c\u5206\u5316\u3002<\/p>","protected":false},"excerpt":{"rendered":"

    Human Epidermal Growth Factor (hEGF)       Human epidermal growth factor (hEGF) is a 53 amino acid polypeptide (Figures 1 and 2) found in our duodenum and salivary glands. It is capable of stimulating cell proliferation and differentiation of various epidermal tissues, such as epidermis of skin, gastrointestinal tract and cornea.  EGF was first … <\/p>\n

    \u7e7c\u7e8c\u95b1\u8b80 “EGF + bFGF”<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"footnotes":""},"class_list":["post-612","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/pages\/612","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/comments?post=612"}],"version-history":[{"count":16,"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/pages\/612\/revisions"}],"predecessor-version":[{"id":1161,"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/pages\/612\/revisions\/1161"}],"wp:attachment":[{"href":"https:\/\/marseille-quince.com\/zh\/wp-json\/wp\/v2\/media?parent=612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}