In oxygen delivery
Nanobubbles have emerged as a viable alternative for tackling major issues in oxygen delivery in a variety of medical settings. In particular, in wound healing, low oxygen levels have a substantial impact on recovery and therapeutic efficacy. Nanobubbles filled with oxygen are a novel option for delivering and retaining oxygen in injured tissues. Furthermore, these small bubbles have the capacity to release oxygen in a regulated manner, which is useful for cleansing wound detritus.
Insufficient oxygen levels caused by hypoxia and ischemia-reperfusion greatly impair wound healing, especially in diabetes. Traditional therapies, such as hyperbaric oxygen therapy and trans-obturator tape therapy, are successful but have limits in terms of cost, cellular toxicity, and application to all wound types. Nanobubbles loaded with oxygen represent a possible option. Their stability in solution allows for sustained oxygen supply to injured tissues.
Nanobubbles’ continuous and focused oxygen supply promotes angiogenesis, or the development of new blood vessels. This procedure is critical for delivering vital nutrients to injured tissue and boosting overall tissue regeneration. Nanobubbles facilitate angiogenesis, which not only addresses the injured tissue’s immediate oxygen demands but also promotes long-term healing by creating an environment suitable to tissue repair and regeneration.In addition to their oxygenating characteristics, nanobubbles can transport therapeutic compounds including growth hormones and antibacterial chemicals. This dual feature enables nanobubbles to address oxygen deficits while simultaneously delivering specialized therapeutic payloads directly to the wound site, hence accelerating the healing process.
Reference:
Topical application of oxygen nano-bubble water enhances the healing process of ischaemic skin wound healing in an animal model
International Wound Journal Volume 19, Issue 7 (2022)
https://onlinelibrary.wiley.com/doi/full/10.1111/iwj.13790
